User:Olivia Gooch/Sandbox 1
From Proteopedia
< User:Olivia Gooch(Difference between revisions)
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== Relevance == | == Relevance == | ||
| + | The human IgM BCR has three domains: extracellular, transmembrane, and intracellular. The antigen binding site (located in the extracellular region) is specific to antigens, but the process is highly conserved across different BCRs. More specifically, the IgM BCR has a unique interaction concerning its Fc chains and a/b subunits. These interactions contribute to the overall structure of the protein. Within the a/b subunits themselves, there are several intermolecular interactions that cause the subunits to remain associated with each other. The following section explores these different domains and interactions in more detail. | ||
== Structural highlights == | == Structural highlights == | ||
Current revision
IgM B-cell Receptor
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References
- ↑ Su Q, Chen M, Shi Y, Zhang X, Huang G, Huang B, Liu D, Liu Z, Shi Y. Cryo-EM structure of the human IgM B cell receptor. Science. 2022 Aug 19;377(6608):875-880. doi: 10.1126/science.abo3923. Epub 2022, Aug 18. PMID:35981043 doi:http://dx.doi.org/10.1126/science.abo3923
Student Contributors
- Olivia Gooch
