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| | <StructureSection load='5ay6' size='340' side='right'caption='[[5ay6]], [[Resolution|resolution]] 1.84Å' scene=''> | | <StructureSection load='5ay6' size='340' side='right'caption='[[5ay6]], [[Resolution|resolution]] 1.84Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5ay6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cauvc Cauvc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AY6 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5ay6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caulobacter_vibrioides_CB15 Caulobacter vibrioides CB15]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AY6 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1io1|1io1]], [[1wlg|1wlg]], [[2d4y|2d4y]], [[2d4x|2d4x]]</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ay6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ay6 OCA], [https://pdbe.org/5ay6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ay6 RCSB], [https://www.ebi.ac.uk/pdbsum/5ay6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ay6 ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">flgE, flaK, CC_0902 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=190650 CAUVC])</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ay6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ay6 OCA], [http://pdbe.org/5ay6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ay6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ay6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ay6 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/FLGE_CAUVC FLGE_CAUVC] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | *[[Flagellar protein 3D structures|Flagellar protein 3D structures]] | | *[[Flagellar protein 3D structures|Flagellar protein 3D structures]] |
| | *[[The Bacterial Flagellar Hook|The Bacterial Flagellar Hook]] | | *[[The Bacterial Flagellar Hook|The Bacterial Flagellar Hook]] |
| - | *[[User:Fadel A. Samatey/FlgE I|User:Fadel A. Samatey/FlgE I]] | |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Cauvc]] | + | [[Category: Caulobacter vibrioides CB15]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Matsunami, H]] | + | [[Category: Matsunami H]] |
| - | [[Category: Samatey, F A]] | + | [[Category: Samatey FA]] |
| - | [[Category: Yoon, Y H]] | + | [[Category: Yoon Y-H]] |
| - | [[Category: Flagellum]]
| + | |
| - | [[Category: Hook]]
| + | |
| - | [[Category: Motor protein]]
| + | |
| - | [[Category: Universal joint]]
| + | |
| Structural highlights
Function
FLGE_CAUVC
Publication Abstract from PubMed
Across bacteria, the protein that makes the flagellar hook, FlgE, has a high variability in amino acid residue composition and sequence length. We hereby present the structure of two fragments of FlgE protein from Campylobacter jejuni and from Caulobacter crescentus, which were obtained by X-ray crystallography, and a high-resolution model of the hook from Caulobacter. By comparing these new structures of FlgE proteins, we show that bacterial hook can be divided in two distinct parts. The first part comprises domains that are found in all FlgE proteins and that will make the basic structure of the hook that is common to all flagellated bacteria. The second part, hyper-variable both in size and structure, will be bacteria dependent. To have a better understanding of the C. jejuni hook, we show that a special strain of Salmonella enterica, which was designed to encode a gene of flgE that has the extra domains found in FlgE from C. jejuni, is fully motile. It seems that no matter the size of the hook protein, the hook will always have a structure made of 11 protofilaments.
Structural insights into bacterial flagellar hooks similarities and specificities.,Yoon YH, Barker CS, Bulieris PV, Matsunami H, Samatey FA Sci Rep. 2016 Oct 19;6:35552. doi: 10.1038/srep35552. PMID:27759043[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Yoon YH, Barker CS, Bulieris PV, Matsunami H, Samatey FA. Structural insights into bacterial flagellar hooks similarities and specificities. Sci Rep. 2016 Oct 19;6:35552. doi: 10.1038/srep35552. PMID:27759043 doi:http://dx.doi.org/10.1038/srep35552
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