1l8w

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[[Image:1l8w.gif|left|200px]]
[[Image:1l8w.gif|left|200px]]
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{{Structure
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|PDB= 1l8w |SIZE=350|CAPTION= <scene name='initialview01'>1l8w</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1l8w", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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{{STRUCTURE_1l8w| PDB=1l8w | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8w OCA], [http://www.ebi.ac.uk/pdbsum/1l8w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l8w RCSB]</span>
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'''Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi'''
'''Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi'''
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[[Category: Sacchettini, J C.]]
[[Category: Sacchettini, J C.]]
[[Category: Sharma, V.]]
[[Category: Sharma, V.]]
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[[Category: variable surface protein]]
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[[Category: Variable surface protein]]
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[[Category: vmp-like sequence]]
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[[Category: Vmp-like sequence]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:40:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:59:42 2008''
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Revision as of 20:40, 2 May 2008

Image:1l8w.gif


PDB ID 1l8w

Drag the structure with the mouse to rotate
1l8w, resolution 2.30Å ()
Non-Standard Residues:
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi


Overview

VlsE is an outer surface lipoprotein of Borrelia burgdorferi that undergoes antigenic variation through an elaborate gene conversion mechanism and is thought to play a major role in the immune response to the Lyme disease borellia. The crystal structure of recombinant variant protein VlsE1 at 2.3-A resolution reveals that the six variable regions form loop structures that constitute most of the membrane distal surface of VlsE, covering the predominantly alpha-helical, invariant regions of the protein. The surface localization of the variable amino acid segments appears to protect the conserved regions from interaction with antibodies and hence may contribute to immune evasion.

About this Structure

1L8W is a Single protein structure of sequence from Borrelia burgdorferi. Full crystallographic information is available from OCA.

Reference

Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi., Eicken C, Sharma V, Klabunde T, Lawrenz MB, Hardham JM, Norris SJ, Sacchettini JC, J Biol Chem. 2002 Jun 14;277(24):21691-6. Epub 2002 Mar 28. PMID:11923306 Page seeded by OCA on Fri May 2 23:40:38 2008

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