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| | <StructureSection load='5dae' size='340' side='right'caption='[[5dae]], [[Resolution|resolution]] 1.40Å' scene=''> | | <StructureSection load='5dae' size='340' side='right'caption='[[5dae]], [[Resolution|resolution]] 1.40Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5dae]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedae Aedae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DAE FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5dae]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DAE FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AAEL006007 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dae OCA], [https://pdbe.org/5dae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dae RCSB], [https://www.ebi.ac.uk/pdbsum/5dae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dae ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dae OCA], [http://pdbe.org/5dae PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dae RCSB], [http://www.ebi.ac.uk/pdbsum/5dae PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dae ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q1HRB8_AEDAE Q1HRB8_AEDAE] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Aedae]] | + | [[Category: Aedes aegypti]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Pereira, P J.B]] | + | [[Category: Pereira PJB]] |
| - | [[Category: Tanaka, A S]] | + | [[Category: Tanaka AS]] |
| - | [[Category: Torquato, R J.S]] | + | [[Category: Torquato RJS]] |
| - | [[Category: Anticoagulant]]
| + | |
| - | [[Category: Inhibitor]]
| + | |
| - | [[Category: Kazal]]
| + | |
| - | [[Category: Protein binding]]
| + | |
| - | [[Category: Trypsin]]
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| Structural highlights
Function
Q1HRB8_AEDAE
Publication Abstract from PubMed
Blood-feeding exoparasites are rich sources of protease inhibitors, and the mosquito Aedes aegypti, which is a vector of Dengue virus, Yellow fever virus, Chikungunya virus and Zika virus, is no exception. AaTI is a single-domain, noncanonical Kazal-type serine proteinase inhibitor from A. aegypti that recognizes both digestive trypsin-like serine proteinases and the central protease in blood clotting, thrombin, albeit with an affinity that is three orders of magnitude lower. Here, the 1.4 A resolution crystal structure of AaTI is reported from extremely tightly packed crystals ( approximately 22% solvent content), revealing the structural determinants for the observed inhibitory profile of this molecule.
High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti.,Torquato RJS, Lu S, Martins NH, Tanaka AS, Pereira PJB Acta Crystallogr F Struct Biol Commun. 2017 Aug 1;73(Pt 8):469-475. doi:, 10.1107/S2053230X17010007. Epub 2017 Jul 26. PMID:28777090[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Torquato RJS, Lu S, Martins NH, Tanaka AS, Pereira PJB. High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti. Acta Crystallogr F Struct Biol Commun. 2017 Aug 1;73(Pt 8):469-475. doi:, 10.1107/S2053230X17010007. Epub 2017 Jul 26. PMID:28777090 doi:http://dx.doi.org/10.1107/S2053230X17010007
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