5en6

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Current revision (08:08, 12 July 2023) (edit) (undo)
 
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==Crystal structure of the Smu1-RED complex (SeMet) of Caenorhabditis elegans==
==Crystal structure of the Smu1-RED complex (SeMet) of Caenorhabditis elegans==
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<StructureSection load='5en6' size='340' side='right' caption='[[5en6]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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<StructureSection load='5en6' size='340' side='right'caption='[[5en6]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5en6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EN6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EN6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5en6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EN6 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.103&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">smu-1, CC4.3, CELE_CC4.3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL]), smu-2, CELE_Y49F6B.4, Y49F6B.4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5en6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5en6 OCA], [http://pdbe.org/5en6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5en6 RCSB], [http://www.ebi.ac.uk/pdbsum/5en6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5en6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5en6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5en6 OCA], [https://pdbe.org/5en6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5en6 RCSB], [https://www.ebi.ac.uk/pdbsum/5en6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5en6 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SMU1_CAEEL SMU1_CAEEL] Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Selectively regulates alternative splicing of unc-52 exon 17 (PubMed:11438655, PubMed:15254247). Thus, smu-1 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17 and enhance the effects of unc-52 mutations that affect the exon 16 splice donor site (PubMed:11438655, PubMed:15254247). In contrast, smu-1 mutants do not suppress unc-52 nonsense mutations in exon 18 (PubMed:11438655).[UniProtKB:Q2TAY7]<ref>PMID:11438655</ref> <ref>PMID:15254247</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Caeel]]
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[[Category: Caenorhabditis elegans]]
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[[Category: Ulrich, A K.C]]
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[[Category: Large Structures]]
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[[Category: Wahl, M C]]
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[[Category: Ulrich AKC]]
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[[Category: Ctlh]]
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[[Category: Wahl MC]]
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[[Category: Dimer]]
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[[Category: Heterotetramer]]
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[[Category: Lish motif]]
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[[Category: Splicing]]
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[[Category: Splicing factor]]
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Current revision

Crystal structure of the Smu1-RED complex (SeMet) of Caenorhabditis elegans

PDB ID 5en6

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