2ovj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:49, 30 August 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='2ovj' size='340' side='right'caption='[[2ovj]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
<StructureSection load='2ovj' size='340' side='right'caption='[[2ovj]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2ovj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OVJ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2ovj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OVJ FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PE:2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL'>7PE</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RACGAP1, KIAA1478, MGCRACGAP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PE:2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL'>7PE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ovj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ovj OCA], [https://pdbe.org/2ovj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ovj RCSB], [https://www.ebi.ac.uk/pdbsum/2ovj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ovj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ovj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ovj OCA], [https://pdbe.org/2ovj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ovj RCSB], [https://www.ebi.ac.uk/pdbsum/2ovj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ovj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/RGAP1_HUMAN RGAP1_HUMAN]] Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.<ref>PMID:10979956</ref> <ref>PMID:9497316</ref> <ref>PMID:11085985</ref> <ref>PMID:11278976</ref> <ref>PMID:11782313</ref> <ref>PMID:14729465</ref> <ref>PMID:15642749</ref> <ref>PMID:16103226</ref> <ref>PMID:16129829</ref> <ref>PMID:16236794</ref> <ref>PMID:19468302</ref> <ref>PMID:19468300</ref>
+
[https://www.uniprot.org/uniprot/RGAP1_HUMAN RGAP1_HUMAN] Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.<ref>PMID:10979956</ref> <ref>PMID:9497316</ref> <ref>PMID:11085985</ref> <ref>PMID:11278976</ref> <ref>PMID:11782313</ref> <ref>PMID:14729465</ref> <ref>PMID:15642749</ref> <ref>PMID:16103226</ref> <ref>PMID:16129829</ref> <ref>PMID:16236794</ref> <ref>PMID:19468302</ref> <ref>PMID:19468300</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 27: Line 27:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Burgess, N]]
+
[[Category: Burgess N]]
-
[[Category: Debreczeni, J]]
+
[[Category: Debreczeni J]]
-
[[Category: Delft, F von]]
+
[[Category: Doyle DA]]
-
[[Category: Doyle, D A]]
+
[[Category: Edwards A]]
-
[[Category: Edwards, A]]
+
[[Category: Elkins J]]
-
[[Category: Elkins, J]]
+
[[Category: Gorrec F]]
-
[[Category: Gorrec, F]]
+
[[Category: Johansson C]]
-
[[Category: Johansson, C]]
+
[[Category: Papagrigoriou E]]
-
[[Category: Papagrigoriou, E]]
+
[[Category: Pike ACW]]
-
[[Category: Pike, A C.W]]
+
[[Category: Shrestha L]]
-
[[Category: Structural genomic]]
+
[[Category: Soundararajan M]]
-
[[Category: Shrestha, L]]
+
[[Category: Sundstrom M]]
-
[[Category: Soundararajan, M]]
+
[[Category: Turnbull A]]
-
[[Category: Sundstrom, M]]
+
[[Category: Umeano C]]
-
[[Category: Turnbull, A]]
+
[[Category: Weigelt J]]
-
[[Category: Umeano, C]]
+
[[Category: Von Delft F]]
-
[[Category: Weigelt, J]]
+
-
[[Category: Sgc]]
+
-
[[Category: Signaling protein]]
+

Current revision

The crystal structure of the human Rac GTPase activating protein 1 (RACGAP1) MgcRacGAP.

PDB ID 2ovj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools