5nnj

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==Dimer structure of Sortilin ectodomain crystal form 3, 4.0 Angstrom==
==Dimer structure of Sortilin ectodomain crystal form 3, 4.0 Angstrom==
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<StructureSection load='5nnj' size='340' side='right' caption='[[5nnj]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
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<StructureSection load='5nnj' size='340' side='right'caption='[[5nnj]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5nnj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NNJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NNJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5nnj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NNJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NNJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sort1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nnj OCA], [http://pdbe.org/5nnj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nnj RCSB], [http://www.ebi.ac.uk/pdbsum/5nnj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nnj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nnj OCA], [https://pdbe.org/5nnj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nnj RCSB], [https://www.ebi.ac.uk/pdbsum/5nnj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nnj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SORT_MOUSE SORT_MOUSE]] Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.<ref>PMID:10594043</ref> <ref>PMID:15236332</ref> <ref>PMID:15236333</ref> <ref>PMID:15372498</ref> <ref>PMID:15992544</ref> <ref>PMID:19407813</ref> <ref>PMID:21102451</ref>
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[https://www.uniprot.org/uniprot/SORT_MOUSE SORT_MOUSE] Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.<ref>PMID:10594043</ref> <ref>PMID:15236332</ref> <ref>PMID:15236333</ref> <ref>PMID:15372498</ref> <ref>PMID:15992544</ref> <ref>PMID:19407813</ref> <ref>PMID:21102451</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5nnj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5nnj" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Neurotensin receptor|Neurotensin receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Janssen, B J.C]]
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[[Category: Mus musculus]]
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[[Category: Leloup, N O.L]]
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[[Category: Janssen BJC]]
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[[Category: Transport protein]]
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[[Category: Leloup NOL]]
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[[Category: Transport receptor]]
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[[Category: Vps10 domain]]
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Current revision

Dimer structure of Sortilin ectodomain crystal form 3, 4.0 Angstrom

PDB ID 5nnj

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