8dqw
From Proteopedia
(Difference between revisions)
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==Open state of Rad24-RFC:9-1-1 bound to a 5' ss/dsDNA junction== | ==Open state of Rad24-RFC:9-1-1 bound to a 5' ss/dsDNA junction== | ||
| - | <StructureSection load='8dqw' size='340' side='right'caption='[[8dqw]]' scene=''> | + | <StructureSection load='8dqw' size='340' side='right'caption='[[8dqw]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DQW FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[8dqw]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DQW FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dqw OCA], [https://pdbe.org/8dqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dqw RCSB], [https://www.ebi.ac.uk/pdbsum/8dqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dqw ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.1Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dqw OCA], [https://pdbe.org/8dqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dqw RCSB], [https://www.ebi.ac.uk/pdbsum/8dqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dqw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RAD17_YEAST RAD17_YEAST] Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Associates with sites of DNA damage and modulates the MEC1 signaling pathway and the activation of RAD53 in response to DNA damage at phase G1. The complex also physically regulates DNA polymerase zeta-dependent mutagenesis by controlling the access of polymerase zeta to damaged DNA. Contrary to its human counterpart, the 9-1-1 complex, the checkpoint clamp complex shows no detectable exonuclease activity.<ref>PMID:12271137</ref> <ref>PMID:12604797</ref> <ref>PMID:12672803</ref> <ref>PMID:16137930</ref> <ref>PMID:16169844</ref> <ref>PMID:7491494</ref> <ref>PMID:8649984</ref> <ref>PMID:9891048</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Hite RK]] | [[Category: Hite RK]] | ||
[[Category: Schrecker M]] | [[Category: Schrecker M]] | ||
Current revision
Open state of Rad24-RFC:9-1-1 bound to a 5' ss/dsDNA junction
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