7t02
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Cryo-EM structure of DNMT5 pseudo-ternary complex solved by incubation with hemimethylated DNA and SAM== |
| - | <StructureSection load='7t02' size='340' side='right'caption='[[7t02]]' scene=''> | + | <StructureSection load='7t02' size='340' side='right'caption='[[7t02]], [[Resolution|resolution]] 3.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7t02]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptococcus_neoformans Cryptococcus neoformans] and [https://en.wikipedia.org/wiki/Cryptococcus_neoformans_var._grubii_H99 Cryptococcus neoformans var. grubii H99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T02 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t02 OCA], [https://pdbe.org/7t02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t02 RCSB], [https://www.ebi.ac.uk/pdbsum/7t02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t02 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t02 OCA], [https://pdbe.org/7t02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t02 RCSB], [https://www.ebi.ac.uk/pdbsum/7t02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t02 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DMT5_CRYNH DMT5_CRYNH] ATP-dependent cytosine methylase that maintains DNA methylation by acting at hemimethylated palindromic 5'-CG-3' sites to produce symmetrically methylated DNA strands (PubMed:24630728, PubMed:31955845, PubMed:32437639). DNA methylation may play a role in transcriptional silencing, particularly at transposable elements (PubMed:24630728).<ref>PMID:24630728</ref> <ref>PMID:31955845</ref> <ref>PMID:32437639</ref> <ref>PMID:24630728</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Cryptococcus neoformans]] | ||
| + | [[Category: Cryptococcus neoformans var. grubii H99]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Patel DJ]] |
| + | [[Category: Wang J]] | ||
Current revision
Cryo-EM structure of DNMT5 pseudo-ternary complex solved by incubation with hemimethylated DNA and SAM
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