6x0l

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==Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin==
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<StructureSection load='6x0l' size='340' side='right'caption='[[6x0l]]' scene=''>
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<StructureSection load='6x0l' size='340' side='right'caption='[[6x0l]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6x0l]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X0L FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6x0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x0l OCA], [http://pdbe.org/6x0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6x0l RCSB], [http://www.ebi.ac.uk/pdbsum/6x0l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6x0l ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x0l OCA], [https://pdbe.org/6x0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x0l RCSB], [https://www.ebi.ac.uk/pdbsum/6x0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x0l ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HPF1_HUMAN HPF1_HUMAN] Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine (PubMed:28190768, PubMed:29480802). Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability (PubMed:27067600, PubMed:28190768). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802). HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1 (PubMed:30257210).<ref>PMID:27067600</ref> <ref>PMID:28190768</ref> <ref>PMID:29480802</ref> <ref>PMID:30257210</ref>
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==See Also==
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*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Synthetic construct]]
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[[Category: Bilokapic S]]
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[[Category: Halic M]]

Revision as of 14:47, 6 March 2024

Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin

PDB ID 6x0l

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