3v69

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Current revision (08:39, 20 March 2024) (edit) (undo)
 
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<StructureSection load='3v69' size='340' side='right'caption='[[3v69]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3v69' size='340' side='right'caption='[[3v69]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3v69]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V69 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3v69]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V69 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BL6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v69 OCA], [https://pdbe.org/3v69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v69 RCSB], [https://www.ebi.ac.uk/pdbsum/3v69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v69 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v69 OCA], [https://pdbe.org/3v69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v69 RCSB], [https://www.ebi.ac.uk/pdbsum/3v69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v69 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/KHDC3_MOUSE KHDC3_MOUSE]] Required for maintenance of euploidy during cleavage-stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. Capable of binding RNA.<ref>PMID:19376971</ref> <ref>PMID:22276159</ref>
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[https://www.uniprot.org/uniprot/KHDC3_MOUSE KHDC3_MOUSE] Required for maintenance of euploidy during cleavage-stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. Capable of binding RNA.<ref>PMID:19376971</ref> <ref>PMID:22276159</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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FILIA is a member of the recently identified oocyte/embryo expressed gene family in eutherian mammals, which is characterized by containing an N-terminal atypical KH domain. Here we report the structure of the N-terminal fragment of FILIA (FILIA-N), which represents the first reported three-dimensional structure of a KH domain in the oocyte/embryo expressed gene family of proteins. The structure of FILIA-N revealed a unique N-terminal extension beyond the canonical KH region, which plays important roles in interaction with RNA. By co-incubation with the lysates of mice ovaries, FILIA and FILIA-N could sequester specific RNA components, supporting the critical roles of FILIA in regulation of RNA transcripts during mouse oogenesis and early embryogenesis.
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The N-terminus of FILIA Forms an Atypical KH Domain with a Unique Extension Involved in Interaction with RNA.,Wang J, Xu M, Zhu K, Li L, Liu X PLoS One. 2012;7(1):e30209. Epub 2012 Jan 19. PMID:22276159<ref>PMID:22276159</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3v69" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Li, L]]
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[[Category: Li L]]
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[[Category: Liu, X]]
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[[Category: Liu X]]
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[[Category: Wang, J]]
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[[Category: Wang J]]
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[[Category: Xu, M]]
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[[Category: Xu M]]
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[[Category: Zhu, K]]
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[[Category: Zhu K]]
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[[Category: Embryogenesis]]
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[[Category: Filia]]
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[[Category: Kh domain]]
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[[Category: Protein binding]]
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[[Category: Rna binding]]
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[[Category: Rna-binding]]
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Current revision

Filia-N crystal structure

PDB ID 3v69

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OCA

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