5ymr

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Current revision (10:24, 27 March 2024) (edit) (undo)
 
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<StructureSection load='5ymr' size='340' side='right'caption='[[5ymr]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='5ymr' size='340' side='right'caption='[[5ymr]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ymr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Desvh Desvh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YMR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YMR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ymr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfovibrio_vulgaris_str._Hildenborough Desulfovibrio vulgaris str. Hildenborough]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YMR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8X3:2-hydroxyethylsulfonic+acid'>8X3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DVU_2824 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=882 DESVH])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8X3:2-hydroxyethylsulfonic+acid'>8X3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ymr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ymr OCA], [http://pdbe.org/5ymr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ymr RCSB], [http://www.ebi.ac.uk/pdbsum/5ymr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ymr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ymr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ymr OCA], [https://pdbe.org/5ymr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ymr RCSB], [https://www.ebi.ac.uk/pdbsum/5ymr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ymr ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/ISLA_DESVH ISLA_DESVH] Involved in an anaerobic respiration pathway that converts the sulfonate isethionate (2-hydroxyethanesulfonate) to ammonia, acetate and sulfide. Catalyzes the radical-mediated C-S bond cleavage of isethionate (2-hydroxyethanesulfonate) to form sulfite and acetaldehyde. Shows no activity with taurine or ethanolamine as substrates.<ref>PMID:30962433</ref>
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Bacterial degradation of organosulfonates plays an important role in sulfur recycling, and has been extensively studied. However, this process in anaerobic bacteria especially gut bacteria is little known despite of its potential significant impact on human health with the production of toxic H2S. Here, we describe the structural and biochemical characterization of an oxygen-sensitive enzyme that catalyzes the radical-mediated C-S bond cleavage of isethionate to form sulfite and acetaldehyde. We demonstrate its involvement in pathways that enables C2 sulfonates to be used as terminal electron acceptors for anaerobic respiration in sulfate- and sulfite-reducing bacteria. Furthermore, it plays a key role in converting bile salt-derived taurine into H2S in the disease-associated gut bacterium Bilophila wadsworthia. The enzymes and transporters in these anaerobic pathways expand our understanding of microbial sulfur metabolism, and help deciphering the complex web of microbial pathways involved in the transformation of sulfur compounds in the gut.
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Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria.,Xing M, Wei Y, Zhou Y, Zhang J, Lin L, Hu Y, Hua G, N Nanjaraj Urs A, Liu D, Wang F, Guo C, Tong Y, Li M, Liu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y Nat Commun. 2019 Apr 8;10(1):1609. doi: 10.1038/s41467-019-09618-8. PMID:30962433<ref>PMID:30962433</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5ymr" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Desvh]]
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[[Category: Desulfovibrio vulgaris str. Hildenborough]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ang, E]]
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[[Category: Ang E]]
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[[Category: Guo, C]]
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[[Category: Guo C]]
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[[Category: Hu, Y]]
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[[Category: Hu Y]]
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[[Category: Hua, G]]
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[[Category: Hua G]]
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[[Category: Lin, L]]
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[[Category: Lin L]]
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[[Category: Wei, Y]]
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[[Category: Wei Y]]
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[[Category: Xing, M]]
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[[Category: Xing M]]
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[[Category: Yuchi, Z]]
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[[Category: Yuchi Z]]
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[[Category: Zhang, J]]
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[[Category: Zhang J]]
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[[Category: Zhang, Y]]
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[[Category: Zhang Y]]
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[[Category: Zhao, H]]
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[[Category: Zhao H]]
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[[Category: C-s bond cleavage]]
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[[Category: Glycyl radical enzyme]]
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[[Category: Isethionate]]
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[[Category: Lyase]]
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Current revision

The Crystal Structure of IseG

PDB ID 5ymr

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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