Ras GTPase-activating protein-binding protein

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== Structural highlights ==
== Structural highlights ==
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G3BP1 contains an N-terminal nuclear transfer factor 2 (NTF2-like) domain, RNA recognition motif domain and Arg-Gly-rich region<ref>PMID:33349931</ref>. The 3D structure of the complex between G3BP1 and Semliki forest virus peptide shows protein:peptide ratio of 2:1. The viral peptide sequence contains twice the tetra peptide FGDF. Each FGDF sequence interacts with one molecule of G3PB1<ref>PMID:27383630</ref>. The viral sequence FGDF interacts with hydrophobic subset and aromatic subsides of G3PB1. <scene name='10/1043572/Test/1'>Test</scene>.
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G3BP1 contains an N-terminal nuclear transfer factor 2 (NTF2-like) domain, RNA recognition motif domain and Arg-Gly-rich region<ref>PMID:33349931</ref>. The 3D structure of the complex between G3BP1 and Semliki forest virus peptide shows protein:peptide ratio of 2:1. The viral peptide sequence contains twice the tetra peptide FGDF. Each FGDF sequence interacts with one molecule of G3PB1<ref>PMID:27383630</ref>. The viral sequence FGDF interacts with hydrophobic subset and aromatic subsides of G3PB1. <scene name='10/1043572/Cv/3'>Test</scene>.
==G3BP 3D structures==
==G3BP 3D structures==

Revision as of 13:14, 24 April 2024

Human G3BP1 NTF2-like domain (cyan, green) complex with Semiliki forest virus peptide (pink), sulfate, acetate, glycerol and K+ (PDB 5fw5)

Drag the structure with the mouse to rotate

References

  1. ↑ Pandey K, Zhong S, Diel DG, Hou Y, Wang Q, Nelson E, Wang X. GTPase-activating protein-binding protein 1 (G3BP1) plays an antiviral role against porcine epidemic diarrhea virus. Vet Microbiol. 2019 Sep;236:108392. PMID:31500725 doi:10.1016/j.vetmic.2019.108392
  2. ↑ Ge Y, Jin J, Li J, Ye M, Jin X. The roles of G3BP1 in human diseases (review). Gene. 2022 May 5;821:146294. PMID:35176431 doi:10.1016/j.gene.2022.146294
  3. ↑ Sidibé H, Dubinski A, Vande Velde C. The multi-functional RNA-binding protein G3BP1 and its potential implication in neurodegenerative disease. J Neurochem. 2021 May;157(4):944-962. PMID:33349931 doi:10.1111/jnc.15280
  4. ↑ Sidibé H, Dubinski A, Vande Velde C. The multi-functional RNA-binding protein G3BP1 and its potential implication in neurodegenerative disease. J Neurochem. 2021 May;157(4):944-962. PMID:33349931 doi:10.1111/jnc.15280
  5. ↑ Schulte T, Liu L, Panas MD, Thaa B, Dickson N, Gotte B, Achour A, McInerney GM. Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication. Open Biol. 2016 Jul;6(7). pii: 160078. doi: 10.1098/rsob.160078. PMID:27383630 doi:http://dx.doi.org/10.1098/rsob.160078

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