Flagellar protein

Function

The bacterial flagellum consists of a filament, a universal joint (hook), and a motor (basal body).

Flagella (singular: flagellum) enable bacteria to swim towards sources of nutrition, and away from sources of toxins. Such directed motility is termed chemotaxis. Rapid swimming helps Bdellovibrio penetrate and parasitize their host bacteria, but flagella are not always essential for virulence^[1]. Flagella are important in responses to quorum sensing^[2] and biofilm formation^[3][4]. Flagella may also be involved in functions other than motility^[5].

• FlgA is essential for P-ring formation in Salmonella and E. coli^[6].
• FlgD is essential for hook assembly in Salmonella^[7].
• FlgE is the subunit of the hook that connects the basal body and the filament^[8].
• FlgG is a rod protein in Salmonella^[9].
• FliD regulates filament assembly by chaperoning Flagellin proteins^[10].

For further information, please see Flagellum at Wikipedia. The bacterial flagellum is made up of about 25 different proteins. There are only a few copies of some proteins, and tens of thousands of copies of the filament protein, FliC. The flagellum is made up of three major regions, as follows.

Motor

At the base of a bacterial flagellum is a reversible motor, also called the basal body. The source of energy driving the motor is an electromotive gradient of, in some bacteria, protons (hydrogen ions, H⁺) or, in other bacteria, sodium ions (Na⁺). The gradient has a higher concentration of ions outside the cell, and a lower concentration of ions inside the cell. Ions flow from outside to inside the bacterial cell, passing through the motor and driving its rotation by a mechanism which is poorly understood.

For more details see Flagellar biosynthetic protein

Filament (Propeller)

The flagellar filament is a relatively rigid, helical rod, typically many times the length of the bacterial cell. Many motile bacteria, including Salmonella, have multiple flagella extending from each cell. Rotation of the filaments by the motor is what propels the cell. More...

For more details see Flagellar proteins and Flagellar filament of bacteria.

Hook (Universal Joint)

The filament is attached to the motor with the flagellar hook, which is a molecular universal joint. The hook is flexible, allowing the angle between the filament and the bacterial cell surface to change over a wide range. However, the hook efficiently transmits torque from the motor to the filament, causing it to rotate.

For details see

• Flagellar hook of bacteria
  
• Samatey/5

Assembly

During assembly of the flagellum, its protein components are transported through hollow cores of the basal body, hook and filament, assembling at the end of the nascent flagellum^[11]. The Namba Group has prepared a movie illustrating their understanding of the assembly process as of about 2004.

3D structures of flagellar protein

Flagellar protein 3D structures