Rho GTPase activating protein
From Proteopedia
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'''Rho GTPase activating protein''' (RhoGAP) are one of the main classes of Rho GTPase regulators that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions<ref>PMID:12480336</ref>,<ref>PMID:17222083</ref>. RhoGAPs contain a RhoGAP domain. | '''Rho GTPase activating protein''' (RhoGAP) are one of the main classes of Rho GTPase regulators that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions<ref>PMID:12480336</ref>,<ref>PMID:17222083</ref>. RhoGAPs contain a RhoGAP domain. | ||
*'''RhoGAP7''' activates the small GTPases RHOA, RHOB, RHOC and CDC42. | *'''RhoGAP7''' activates the small GTPases RHOA, RHOB, RHOC and CDC42. | ||
| + | *'''RhoGAP9''' regulates adhesion of hematopoietic cells to the extracellular matrix. | ||
== Relevance == | == Relevance == | ||
Revision as of 07:13, 7 August 2024
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References
- ↑ Moon SY, Zheng Y. Rho GTPase-activating proteins in cell regulation. Trends Cell Biol. 2003 Jan;13(1):13-22. PMID:12480336
- ↑ Tcherkezian J, Lamarche-Vane N. Current knowledge of the large RhoGAP family of proteins. Biol Cell. 2007 Feb;99(2):67-86. doi: 10.1042/BC20060086. PMID:17222083 doi:http://dx.doi.org/10.1042/BC20060086
- ↑ Kandpal RP. Rho GTPase activating proteins in cancer phenotypes. Curr Protein Pept Sci. 2006 Aug;7(4):355-65. PMID:16918449
- ↑ Song W, Chen J, Li S, Li D, Zhang Y, Zhou H, Yu W, He B, Zhang W, Li L. Rho GTPase Activating Protein 9 (ARHGAP9) in Human Cancers. Recent Pat Anticancer Drug Discov. 2022;17(1):55-65. PMID:34365932 doi:10.2174/1574892816666210806155754
- ↑ Graham DL, Lowe PN, Grime GW, Marsh M, Rittinger K, Smerdon SJ, Gamblin SJ, Eccleston JF. MgF(3)(-) as a transition state analog of phosphoryl transfer. Chem Biol. 2002 Mar;9(3):375-81. PMID:11927263
