Spermidine/spermine N-acetyltransferase
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
== Function == | == Function == | ||
'''Spermidine/spermine N-acetyltransferase''' (SSAT) or '''Spermidine N-acetyltransferase''' or '''diamine acetyltransferase''' catalyzes the acetylation of spermidine and spermine. SSAT regulates cellular polyamine homeostasis by degrading polyamines via their acetylation. SSAT activity is regulated by polyamine concentration and various toxins, hormones and natural products<ref>PMID:18349109</ref>. | '''Spermidine/spermine N-acetyltransferase''' (SSAT) or '''Spermidine N-acetyltransferase''' or '''diamine acetyltransferase''' catalyzes the acetylation of spermidine and spermine. SSAT regulates cellular polyamine homeostasis by degrading polyamines via their acetylation. SSAT activity is regulated by polyamine concentration and various toxins, hormones and natural products<ref>PMID:18349109</ref>. | ||
| + | *'''Spermidine/spermine N-acetyltransferase SpeG''' is a bacterial SSAT with a unique dodecameric structure and allosteric site<ref>PMID:37508494</ref>. | ||
== Relevance == | == Relevance == | ||
Revision as of 07:04, 14 August 2024
| |||||||||||
3D structures of SSAT
14-August-2024
References
- ↑ Pegg AE. Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator. Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E995-1010. doi:, 10.1152/ajpendo.90217.2008. Epub 2008 Mar 18. PMID:18349109 doi:http://dx.doi.org/10.1152/ajpendo.90217.2008
- ↑ Tsimbalyuk S, Shornikov A, Srivastava P, Le VTB, Warren I, Khandokar YB, Kuhn ML, Forwood JK. Structural and Kinetic Characterization of the SpeG Spermidine/Spermine N-acetyltransferase from Methicillin-Resistant Staphylococcus aureus USA300. Cells. 2023 Jul 12;12(14):1829. PMID:37508494 doi:10.3390/cells12141829
- ↑ Allen WL, McLean EG, Boyer J, McCulla A, Wilson PM, Coyle V, Longley DB, Casero RA Jr, Johnston PG. The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells. Mol Cancer Ther. 2007 Jan;6(1):128-37. PMID:17237273 doi:http://dx.doi.org/10.1158/1535-7163.MCT-06-0303
- ↑ Hegde SS, Chandler J, Vetting MW, Yu M, Blanchard JS. Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase. Biochemistry. 2007 Jun 19;46(24):7187-95. Epub 2007 May 22. PMID:17516632 doi:10.1021/bi700256z
