8tlk
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==CDCA7 (Human) Binds Non-B-form 32-mer DNA oligo Containing a 5mC== | |
| - | + | <StructureSection load='8tlk' size='340' side='right'caption='[[8tlk]], [[Resolution|resolution]] 2.99Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8tlk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TLK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TLK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tlk OCA], [https://pdbe.org/8tlk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tlk RCSB], [https://www.ebi.ac.uk/pdbsum/8tlk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tlk ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/CDCA7_HUMAN CDCA7_HUMAN] ICF syndrome. The disease may be caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CDCA7_HUMAN CDCA7_HUMAN] Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator.<ref>PMID:11598121</ref> <ref>PMID:15994934</ref> <ref>PMID:16580749</ref> <ref>PMID:23166294</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Cheng X]] | ||
| + | [[Category: Horton JR]] | ||
| + | [[Category: Ren R]] | ||
Current revision
CDCA7 (Human) Binds Non-B-form 32-mer DNA oligo Containing a 5mC
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