1umg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1umg.gif|left|200px]]
[[Image:1umg.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1umg |SIZE=350|CAPTION= <scene name='initialview01'>1umg</scene>, resolution 1.80&Aring;
+
The line below this paragraph, containing "STRUCTURE_1umg", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=2FP:1,6-FRUCTOSE+DIPHOSPHATE+(LINEAR+FORM)'>2FP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= ST0318 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111955 Sulfolobus tokodaii])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1umg| PDB=1umg | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1umg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1umg OCA], [http://www.ebi.ac.uk/pdbsum/1umg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1umg RCSB]</span>
+
-
}}
+
'''Crystal strucure of fructose-1,6-bisphosphatase'''
'''Crystal strucure of fructose-1,6-bisphosphatase'''
Line 30: Line 27:
[[Category: Shoun, H.]]
[[Category: Shoun, H.]]
[[Category: Wakagi, T.]]
[[Category: Wakagi, T.]]
-
[[Category: alpha-beta-beta-alpha four layer sandwich]]
+
[[Category: Alpha-beta-beta-alpha four layer sandwich]]
-
[[Category: fructose-1,6-bisphosphatase]]
+
[[Category: Fructose-1,6-bisphosphatase]]
-
[[Category: hyperthermophilic archaea]]
+
[[Category: Hyperthermophilic archaea]]
-
[[Category: magnesium ion]]
+
[[Category: Magnesium ion]]
-
[[Category: octamer]]
+
[[Category: Octamer]]
-
[[Category: phosphatase]]
+
[[Category: Phosphatase]]
-
[[Category: three metal-assisted mechanism]]
+
[[Category: Three metal-assisted mechanism]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:25:40 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:12:16 2008''
+

Revision as of 08:25, 3 May 2008

Image:1umg.gif

Template:STRUCTURE 1umg

Crystal strucure of fructose-1,6-bisphosphatase


Overview

As the first structure of the novel class of fructose-1,6-bisphosphatase (FBPase) present in thermophilic archaea, we solved the crystal structure of the ST0318 gene product (St-Fbp) of Sulfolobus tokodaii strain 7. The St-Fbp structure comprises a homooctamer of the 422 point-group. The protein folds as a four-layer alpha-beta-beta-alpha sandwich with a novel topology, which is completely different from the sugar phosphatase fold. The structure contains an unhydrolyzed FBP molecule in the open-keto form, as well as four hexacoordinated magnesium ions around the 1-phosphoryl group of FBP. The arrangement of the catalytic side chains and metal ligands is consistent with the three-metal ion assisted catalysis proposed for conventional FBPases. The structure provides an insight into the structural basis of the strict substrate specificity of St-Fbp.

About this Structure

1UMG is a Single protein structure of sequence from Sulfolobus tokodaii. Full crystallographic information is available from OCA.

Reference

The first crystal structure of the novel class of fructose-1,6-bisphosphatase present in thermophilic archaea., Nishimasu H, Fushinobu S, Shoun H, Wakagi T, Structure. 2004 Jun;12(6):949-59. PMID:15274916 Page seeded by OCA on Sat May 3 11:25:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1umg"
Personal tools