8y6m
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The structure of Oryza sativa HKT2;1== |
| + | <StructureSection load='8y6m' size='340' side='right'caption='[[8y6m]], [[Resolution|resolution]] 2.91Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8y6m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Oryza_sativa_Indica_Group_x_Oryza_nivara Oryza sativa Indica Group x Oryza nivara]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y6M FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.91Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y6m OCA], [https://pdbe.org/8y6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y6m RCSB], [https://www.ebi.ac.uk/pdbsum/8y6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y6m ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/HKT21_ORYSI HKT21_ORYSI] Seems to be involved in regulation of potassium-sodium homeostasis (PubMed:11489190, PubMed:11959905, PubMed:12182709, PubMed:12795699). Seems to act as a high-affinity sodium transporter, which mediates increased sodium uptake in roots under potassium deficiency and contributes to sodium accumulation and salt toxicity (PubMed:11489190, PubMed:11959905, PubMed:12182709, PubMed:12795699). Involved in nutritional sodium uptake and distribution in potassium-starved roots to allow plant growth (By similarity). May also act as a potassium transporter (PubMed:11489190, PubMed:11959905, PubMed:12182709, PubMed:12795699). Functions as a sodium-potassium cotransporter (By similarity).[UniProtKB:Q0D9S3]<ref>PMID:11489190</ref> <ref>PMID:11959905</ref> <ref>PMID:12182709</ref> <ref>PMID:12795699</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The high-affinity potassium transporters (HKTs), selectively permeable to either Na(+) alone or Na(+)/K(+), play pivotal roles in maintaining plant Na(+)/K(+) homeostasis. Although their involvement in salt tolerance is widely reported, the molecular underpinnings of Oryza sativa HKTs remain elusive. In this study, we elucidate the structures of OsHKT1;1 and OsHKT2;1, representing two distinct classes of rice HKTs. The dimeric assembled OsHKTs can be structurally divided into four domains. At the dimer interface, a half-helix or a loop in the third domain is coordinated by the C-terminal region of the opposite subunit. Additionally, we present the structures of OsHKT1;5 salt-tolerant and salt-sensitive variants, a key quantitative trait locus associated with salt tolerance. The salt-tolerant variant of OsHKT1;5 exhibits enhanced Na(+) transport capability and displays a more flexible conformation. These findings shed light on the molecular basis of rice HKTs and provide insights into their role in salt tolerance. | ||
| - | + | Structural insights into the Oryza sativa cation transporters HKTs in salt tolerance.,Gao R, Jia Y, Xu X, Fu P, Zhou J, Yang G J Integr Plant Biol. 2024 Apr;66(4):700-708. doi: 10.1111/jipb.13632. Epub 2024 , Feb 26. PMID:38409933<ref>PMID:38409933</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 8y6m" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Oryza sativa Indica Group x Oryza nivara]] | ||
| + | [[Category: Fu P]] | ||
| + | [[Category: Gao R]] | ||
| + | [[Category: Jia YT]] | ||
| + | [[Category: Xu X]] | ||
| + | [[Category: Yang GH]] | ||
| + | [[Category: Zhou JQ]] | ||
Current revision
The structure of Oryza sativa HKT2;1
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