Synthetic nanomaterials from standardized protein blocks
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In March, 2024, Huddy ''et al.'' in the team of David Baker (subsequently a [[Nobel_Prizes_for_3D_Molecular_Structure#2020-2029|Nobel Laureate]]) published a wide range of synthetic protein nanostructures self-assembled from standardized, engineered alpha-helical protein modules<ref name="huddy2024">PMID: 38480887</ref>. The extensively documented report, in ''Nature'', has 32 authors. | In March, 2024, Huddy ''et al.'' in the team of David Baker (subsequently a [[Nobel_Prizes_for_3D_Molecular_Structure#2020-2029|Nobel Laureate]]) published a wide range of synthetic protein nanostructures self-assembled from standardized, engineered alpha-helical protein modules<ref name="huddy2024">PMID: 38480887</ref>. The extensively documented report, in ''Nature'', has 32 authors. | ||
| - | The breakthrough here is that instead of designing a single desired nanostructure, the Baker group has first designed a series of regular building blocks that can be assembled into diverse nanostructures using straightforward geometric principles. These now enable "construction of protein nanomaterials according to ‘back of an envelope’ architectural blueprints"<ref name="huddy2024" />. | + | The breakthrough here is that instead of designing a single "one-off" desired nanostructure, the Baker group has first designed a series of regular building blocks that can be assembled into diverse nanostructures using straightforward geometric principles. These now enable "construction of protein nanomaterials according to ‘back of an envelope’ architectural blueprints"<ref name="huddy2024" />. |
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== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 16:32, 23 December 2024
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References
- ↑ 1.0 1.1 Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Weidle C, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Han HL, Carr KD, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D. Blueprinting extendable nanomaterials with standardized protein blocks. Nature. 2024 Mar;627(8005):898-904. PMID:38480887 doi:10.1038/s41586-024-07188-4
