Synthetic nanomaterials from standardized protein blocks
From Proteopedia
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Dozens of types of building blocks were designed, synthesized, purified, and their structures and assemblies were determined<ref name="huddy2024" />. <scene name='10/1068508/5_building_block_modules/1'>Here are shown five examples having specified angles within or between pairs of protein chains</scene><ref>The five modules shown are from the following assemblies that can be downloaded as PDB files from supplementary materials of Huddy ''et al,'', 2024:</ref>. | Dozens of types of building blocks were designed, synthesized, purified, and their structures and assemblies were determined<ref name="huddy2024" />. <scene name='10/1068508/5_building_block_modules/1'>Here are shown five examples having specified angles within or between pairs of protein chains</scene><ref>The five modules shown are from the following assemblies that can be downloaded as PDB files from supplementary materials of Huddy ''et al,'', 2024:</ref>. | ||
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| + | ==Assemblies== | ||
| + | Building blocks were designed to attach to each other in specific geometries. They self-assembled into the predicted assemblies, including: | ||
==Related Work== | ==Related Work== | ||
Revision as of 19:02, 4 January 2025
This page is under construction. This notice will be removed when it is ready. Eric Martz 21:20, 23 December 2024 (UTC) |
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References
- ↑ 1.0 1.1 1.2 1.3 Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Weidle C, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Han HL, Carr KD, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D. Blueprinting extendable nanomaterials with standardized protein blocks. Nature. 2024 Mar;627(8005):898-904. PMID:38480887 doi:10.1038/s41586-024-07188-4
- ↑ An amino-terminal histidine tag was not resolved in the electron density map of 8g9j, and thus is missing in the structure depicted.
- ↑ The five modules shown are from the following assemblies that can be downloaded as PDB files from supplementary materials of Huddy et al,, 2024:
- ↑ Wang S, Favor A, Kibler R, Lubner J, Borst AJ, Coudray N, Redler RL, Chiang HT, Sheffler W, Hsia Y, Li Z, Ekiert DC, Bhabha G, Pozzo LD, Baker D. Bond-centric modular design of protein assemblies. bioRxiv [Preprint]. 2024 Oct 12:2024.10.11.617872. PMID:39416012 doi:10.1101/2024.10.11.617872
