8qmd
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Human NK cell receptor NKp80, extracellular domain== | |
| - | + | <StructureSection load='8qmd' size='340' side='right'caption='[[8qmd]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8qmd]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QMD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qmd OCA], [https://pdbe.org/8qmd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qmd RCSB], [https://www.ebi.ac.uk/pdbsum/8qmd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qmd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KLRF1_HUMAN KLRF1_HUMAN] Functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases (PubMed:21149606).<ref>PMID:17057721</ref> <ref>PMID:21149606</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Blaha J]] | ||
| + | [[Category: Kalouskova B]] | ||
| + | [[Category: Pazderova K]] | ||
| + | [[Category: Vanek O]] | ||
| + | [[Category: Wilmanns M]] | ||
Current revision
Human NK cell receptor NKp80, extracellular domain
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