Sandbox Donepezil

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(New page: ==Your Heading Here (maybe something like 'Structure')== <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> This is a default text for you...)
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==Your Heading Here (maybe something like 'Structure')==
==Your Heading Here (maybe something like 'Structure')==
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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<StructureSection load='' size='490' side='right' caption='Donepezil, also known as Aricept' scene='Donepezil/Donepezil/1'>
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This is a default text for your page '''Sandbox Donepezil'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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===Better Known as: Aricept===
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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* Marketed By: Eisai & Pfizer <br />
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* Major Indication: [[Alzheimer's Disease]]<br />
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* Drug Class: [[Acetylcholinesterase]] Inhibitor
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* Date of FDA Approval (Patent Expiration): 1996 (2008)<br />
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* 2006 Sales: $1.4 Billion<ref>Irena Melnikova, Therapies for Alzheimer's disease, Nature Reviews Drug Discovery 6, 341-342 (May 2007)</ref>
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* Importance: One of the most effective treatments for the symptoms of [[Alzheimer's Disease]], although no definitive proof exists as to whether it alters the progression of the disease.
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* See: [[Pharmaceutical Drugs]] for more information about other drugs and disorders
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== Function ==
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===Mechanism of Action===
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Donepezil is a potent [[Acetylcholinesterase]] (AChE) inhibitor to the active site of <scene name='42/428165/Ache/6'>AChE</scene>. By inhibiting AChE, the important neurotransmitter, [[acetylcholine]], is degraded at a slower rate, helping reverse the marked decrease in neuronal function evident in [[Alzheimer's Disease]] patients. Donepezil binds along the active-site gorge, extending from the anionic subsite <scene name='Donepezil/Trp_84/1'>near Trp 84</scene> to the peripheral anionic site <scene name='Donepezil/Trp_279/1'>near Trp 279</scene>. Interestingly, it does not directly interact with the catalytic triad of acetylcholinesterase nor the oxyanion hole. Further, donepezil does not form any direct hydrogen bonds with AChE nor electrostatic interactions, but rather only interacts via aromatic stacking and solvent mediated interactions. It <scene name='Donepezil/Bound/1'>primarily interacts</scene> with Glu 199, His 440, Phe 330, Trp 84, Tyr 334, Tyr 121, Phe 331, Phe 288, Ser 286, Phe 290, Arg 289, Trp 279, & Leu 282 to tightly bind to AChE<ref name="Kryger">PMID:10368299</ref>. More details can be seen at [[Aricept_Complexed_with_Acetylcholinesterase]].
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== Disease ==
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===Pharmacokinetics===
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{{:Acetylcholinesterase Inhibitor Pharmacokinetics}}
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</td>
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</tr>
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</table>
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== Relevance ==
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===References===
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<references/>
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== Structural highlights ==
 
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
 
</StructureSection>
</StructureSection>
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== References ==
 
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<references/>
 

Revision as of 15:35, 11 June 2025

Your Heading Here (maybe something like 'Structure')

Donepezil, also known as Aricept

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