User:Letícia Oliveira Rojas Cruz/Sandbox 1

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== Structure information ==
== Structure information ==
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The ACE2 protein has
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The ACE2 protein gene has 40 kb and 18 exons. Its protein has 805 amino acids with a molecular weight of 120 kDa. Here, we have a view of the <scene name='10/1083732/Ace2_completa/1'>full ACE2 protein</scene>. It can be divided into 4 portions: Peptidase Domain (Residues 19–615), Collectrin-like Domain (Residues 616–740), Transmembrane Domain (Residues 741–761) and Intracellular C-terminal Tail (Residues 762–805), from N-terminal to C-terminal.
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The Peptidase domain is responsible for the enzymatic activity of ACE2. This domain can be divided in two subdomains: Subdomain I and Subdomain II. Together, they form a substrate-binding cleft, where is located the catalytic site. Within this site, a zinc-ion is associated with the residues His374, His378, and Glu402, which are going to perform a nucleophilic attack on the peptide bond of the substrate, leading to its cleavage.
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== Function ==
== Function ==

Revision as of 12:42, 22 June 2025

Introduction

Caption for this structure

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References

  1. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  3. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024

Proteopedia Page Contributors and Editors (what is this?)

Letícia Oliveira Rojas Cruz

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