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The ACE2 protein can associate with the neutral amino acid transporter B0AT1, also known as SLC6A19. In this context, ACE2 first forms a homodimer, where two ACE2 molecules interact side by side. Each ACE2 monomer then binds to one B0AT1 molecule. This results in a complex composed of two ACE2 and two B0AT1 molecules, which is commonly described as a dimer of heterodimers. This association is essential for the transport of neutral amino acids in intestinal cells and the anchoring of ACE2 in the cell membrane, keeping the catalytic site facing the extracellular environment. Although ACE2 dimerization occurs independently of B0AT1, the transporter plays a stabilizing role by interacting with the Collectrin-like Domain.
The ACE2 protein can associate with the neutral amino acid transporter B0AT1, also known as SLC6A19. In this context, ACE2 first forms a homodimer, where two ACE2 molecules interact side by side. Each ACE2 monomer then binds to one B0AT1 molecule. This results in a complex composed of two ACE2 and two B0AT1 molecules, which is commonly described as a dimer of heterodimers. This association is essential for the transport of neutral amino acids in intestinal cells and the anchoring of ACE2 in the cell membrane, keeping the catalytic site facing the extracellular environment. Although ACE2 dimerization occurs independently of B0AT1, the transporter plays a stabilizing role by interacting with the Collectrin-like Domain.
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This ACE2-B0AT1 complex is anchored to the cell plasma membrane, keeping the ACE2 protein in an extracellular environment. The intermembrane region has apolar characteristics, since it must interact with the hydrophobic tails of the phospholipids. Analyzing the polarity of the complex, an apolar (in gray) region is observed in the B0AT1 region, showing that it is in this region where the complex is in contact with the plasma membrane. The polar regions (CLD and PD domains of ACE2) are located in the external region, without contact with the apolar region of the phospholipids.
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This ACE2-B0AT1 complex is anchored to the cell plasma membrane, keeping the ACE2 protein in an extracellular environment. The intermembrane region has apolar characteristics, since it must interact with the hydrophobic tails of the phospholipids. Analyzing the polarity of the complex, an '''{{Font color|gray|apolar region}}''' is observed in the B0AT1 region, showing that it is in this region where the complex is in contact with the plasma membrane. The '''{{Font color|orchid|polar regions}}''' (CLD and PD domains of ACE2) are located in the external region, without contact with the apolar region of the phospholipids.
=== ACE2 Dimerization ===
=== ACE2 Dimerization ===

Revision as of 20:45, 22 June 2025

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PDB 6m17

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