User:Letícia Oliveira Rojas Cruz/Sandbox 1

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== Physiological Function ==
== Physiological Function ==
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ACE2 is a transmembrane glycoprotein that has an extracellular catalytic domain. It is classified as a hydrolase, more specifically a carboxypeptidase-type peptidase, responsible for the cleavage of peptide bonds at the C-terminal site.
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<scene name='10/1083732/Ace2_completa/3'>ACE2</scene> is a transmembrane glycoprotein that has an extracellular catalytic domain. It is classified as a hydrolase, more specifically a carboxypeptidase-type peptidase, responsible for the cleavage of peptide bonds at the C-terminal site.
The ACE2 acts to cleave a single C-terminal residue of some substrates. One of those substrates is Angiotensin II (Ang II), which is degrated into Angiotensin-(1-7); to a lesser extent, Angiotensin I (Ang I) is also a substrate, turning in into Angiotensin-(1-9).
The ACE2 acts to cleave a single C-terminal residue of some substrates. One of those substrates is Angiotensin II (Ang II), which is degrated into Angiotensin-(1-7); to a lesser extent, Angiotensin I (Ang I) is also a substrate, turning in into Angiotensin-(1-9).
The Renin-Angiotensin System - "RAS" -, in which ACE2 acts, is an important signaling pathway responsible for vascular homeostasis.
The Renin-Angiotensin System - "RAS" -, in which ACE2 acts, is an important signaling pathway responsible for vascular homeostasis.

Revision as of 20:55, 22 June 2025

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PDB 6m17

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