User:Letícia Oliveira Rojas Cruz/Sandbox 1

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'''''Domain PD Interation'''''
'''''Domain PD Interation'''''
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In addition to the CLD, the Peptidase Domain (PD) also contributes to ACE2 dimerization. The amino acids Cys133, Asn134, Asp136, Asn137, Gln139, Glu140, and Cys141 form a <scene name='10/1078774/Lig_hidrogenio/2'>loop</scene> region within the PD. The two cysteines (Cys133 and Cys141) establish a disulfide bond, which stabilizes the loop conformation, supported by additional intraloop polar interactions. Furthermore, Gln139 forms a polar interaction with Gln175 from the other ACE2 monomer.
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In addition to the CLD, the Peptidase Domain (PD) also contributes to ACE2 dimerization. The amino acids Cys133, Asn134, Asp136, Asn137, Gln139, Glu140, and Cys141 form a loop region within the PD. The two cysteines (Cys133 and Cys141) establish a disulfide bond, which stabilizes the loop conformation, supported by additional intraloop polar interactions. Furthermore, Gln139 forms a polar interaction with Gln175 from the other ACE2 monomer.
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=== SARS-CoV-2 Binding ===
=== SARS-CoV-2 Binding ===

Revision as of 21:53, 22 June 2025

Introduction

PDB 6m17

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Letícia Oliveira Rojas Cruz

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