User:Letícia Oliveira Rojas Cruz/Sandbox 1

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'''''Domain PD Interation'''''
'''''Domain PD Interation'''''
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In addition to the CLD, the Peptidase Domain (PD) also contributes to ACE2 dimerization. The amino acids '''{{Font color|slateblue|Cys133}}''', '''{{Font color|slateblue|Asn134}}''', '''{{Font color|slateblue|Asp136}}''', '''{{Font color|slateblue|Asn137}}''', '''{{Font color|slateblue|Gln139}}''', '''{{Font color|slateblue|Glu140}}''', and '''{{Font color|slateblue|Cys141}}''' form a <scene name='10/1078774/Lig_hidrogenio/2'>loop</scene> region within the PD. The two cysteines ('''{{Font color|slateblue|Cys133}}''' and '''{{Font color|slateblue|Cys141}}''') establish a disulfide bond, which stabilizes the loop conformation, supported by additional intraloop polar interactions. Furthermore, '''{{Font color|slateblue|Gln139}}''' forms a polar interaction with '''{{Font color|turquoise|Gln175}}''' from the other ACE2 monomer.
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In addition to the CLD, the Peptidase Domain (PD) also contributes to ACE2 dimerization. The amino acids '''{{Font color|slateblue|Cys133}}''', '''{{Font color|slateblue|Asn134}}''', '''{{Font color|slateblue|Asp136}}''', '''{{Font color|slateblue|Asn137}}''', '''{{Font color|slateblue|Gln139}}''', '''{{Font color|slateblue|Glu140}}''', and '''{{Font color|slateblue|Cys141}}''' form a <scene name='10/1083732/Loop_pd/1'>loop</scene> region within the PD. The two cysteines ('''{{Font color|slateblue|Cys133}}''' and '''{{Font color|slateblue|Cys141}}''') establish a disulfide bond, which stabilizes the loop conformation, supported by additional intraloop polar interactions. Furthermore, '''{{Font color|slateblue|Gln139}}''' forms a polar interaction with '''{{Font color|turquoise|Gln175}}''' from the other ACE2 monomer.
=== SARS-CoV-2 Binding ===
=== SARS-CoV-2 Binding ===

Revision as of 22:49, 22 June 2025

Introduction

PDB 6m17

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Letícia Oliveira Rojas Cruz

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