9vkf
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of yeast arginine N-methyltransferase 1,HMT1== | |
| - | + | <StructureSection load='9vkf' size='340' side='right'caption='[[9vkf]], [[Resolution|resolution]] 2.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9vkf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VKF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vkf OCA], [https://pdbe.org/9vkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vkf RCSB], [https://www.ebi.ac.uk/pdbsum/9vkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vkf ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Shang | + | [https://www.uniprot.org/uniprot/ANM1_YEAST ANM1_YEAST] S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that catalyzes both the mono- and asymmetric (type I) dimethylation of the guanidino nitrogens of arginine residues in a variety of RNA-binding proteins such as heterogeneous nuclear ribonucleoproteins (hnRNPs) and small nuclear ribonucleoproteins (snRNPs) (PubMed:8647869, PubMed:8668183). Methylates NAB2, NPL3, HRP1 and YRA1, shuttling hnRNPs involved in mRNA processing and export, facilitating their export out of the nucleus (PubMed:10652296, PubMed:11779864, PubMed:15314027, PubMed:8668183, PubMed:9499403). Methylation of NPL3 weakens its interaction with THO2, a component of the TREX (transcription/export) complex important for transcriptional elongation and recruitment of mRNA export factors (PubMed:15314027, PubMed:20053728). Methylates the hnRNP HRB1, but does not influence its subcellular location (PubMed:9499403). Methylates the nucleolar proteins GAR1, NOP1 and NSR1 (PubMed:12756332). Methylates the snRNP SNP1 and modulates the cotranscriptional recruitment of splicing factors (PubMed:20823272). Dimethylates free histone H4 (HHF1/HHF2) at 'Arg-4' (H4R3me2a) and plays a role in preservation and establishment of silent chromatin domains (PubMed:12097318, PubMed:17158743). Mono- and dimethylates ribosomal protein S2 (RPS2) at 'Arg-11' (PubMed:20035717). Methylates the catalytic subunit of the SWI/SNF chromatin-remodeling complex SNF2 (PubMed:22997150).<ref>PMID:10652296</ref> <ref>PMID:11101900</ref> <ref>PMID:11779864</ref> <ref>PMID:12097318</ref> <ref>PMID:12756332</ref> <ref>PMID:15314027</ref> <ref>PMID:17158743</ref> <ref>PMID:20035717</ref> <ref>PMID:20053728</ref> <ref>PMID:20823272</ref> <ref>PMID:22997150</ref> <ref>PMID:8647869</ref> <ref>PMID:8668183</ref> <ref>PMID:9499403</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae S288C]] | ||
| + | [[Category: Liu YL]] | ||
| + | [[Category: Shang XC]] | ||
| + | [[Category: Yang XY]] | ||
| + | [[Category: Zhou YH]] | ||
Current revision
Crystal structure of yeast arginine N-methyltransferase 1,HMT1
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