8zt5

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Current revision (08:02, 16 July 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8zt5 is ON HOLD until 2026-06-06
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==Structure of calcium preference ATP-gated channel P2X1 in the Desensitized state 2 in the presence of 1mM Calcium ion==
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<StructureSection load='8zt5' size='340' side='right'caption='[[8zt5]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8zt5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZT5 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zt5 OCA], [https://pdbe.org/8zt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zt5 RCSB], [https://www.ebi.ac.uk/pdbsum/8zt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zt5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P2RX1_MOUSE P2RX1_MOUSE] ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability (By similarity). Furthermore, CTP functions as a weak affinity agonist for P2RX1 (By similarity). Plays a role in male fertility, bladder contraction and platelet aggregation (PubMed:10638758, PubMed:11090125, PubMed:19635923, PubMed:25150292). Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function (PubMed:10638758). In addition, contributes to smooth muscle contractions of the urinary bladder (PubMed:11090125). On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis (PubMed:25150292). On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells (PubMed:19635923).[UniProtKB:P51575]<ref>PMID:10638758</ref> <ref>PMID:11090125</ref> <ref>PMID:19635923</ref> <ref>PMID:25150292</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Xu HE]]
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[[Category: Zhang H]]

Current revision

Structure of calcium preference ATP-gated channel P2X1 in the Desensitized state 2 in the presence of 1mM Calcium ion

PDB ID 8zt5

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OCA

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