GTPase KRas
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
'''GTPase KRas''' (KRas) plays a critical role in the control of cellular growth. Kras stands for Kirsten rat sarcoma virus gene. KRas is a small GTPase that functions as molecular switches by alternating | '''GTPase KRas''' (KRas) plays a critical role in the control of cellular growth. Kras stands for Kirsten rat sarcoma virus gene. KRas is a small GTPase that functions as molecular switches by alternating | ||
between inactive GDP-bound state and active GTP-bound state<ref>PMID:2406906</ref>. | between inactive GDP-bound state and active GTP-bound state<ref>PMID:2406906</ref>. | ||
| - | KRas4A and KRas4B are two isoforms of KRas differing in 15 residues which are involved in trafficking and in membrane localisation<ref>PMID:38354232</ref>. | + | '''KRas4A''' and '''KRas4B''' are two isoforms of KRas differing in 15 residues which are involved in trafficking and in membrane localisation<ref>PMID:38354232</ref>. |
== Disease == | == Disease == | ||
Current revision
| |||||||||||
References
- ↑ Milburn MV, Tong L, deVos AM, Brunger A, Yamaizumi Z, Nishimura S, Kim SH. Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science. 1990 Feb 23;247(4945):939-45. PMID:2406906
- ↑ Whitley MJ, Tran TH, Rigby M, Yi M, Dharmaiah S, Waybright TJ, Ramakrishnan N, Perkins S, Taylor T, Messing S, Esposito D, Nissley DV, McCormick F, Stephen AG, Turbyville T, Cornilescu G, Simanshu DK. Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties. Sci Adv. 2024 Feb 16;10(7):eadj4137. PMID:38354232 doi:10.1126/sciadv.adj4137
- ↑ Shibata H, Ohike N, Norose T, Isobe T, Suzuki R, Imai H, Shiokawa A, Aoki T, Murakami M, Mizukami H, Tanaka JI, Takimoto M. Mucinous Cystic Neoplasms Lined by Abundant Mucinous Epithelium Frequently Involve KRAS Mutations and Malignant Progression. Anticancer Res. 2017 Dec;37(12):7063-7068. doi: 10.21873/anticanres.12178. PMID:29187496 doi:http://dx.doi.org/10.21873/anticanres.12178
- ↑ Sun Q, Burke JP, Phan J, Burns MC, Olejniczak ET, Waterson AG, Lee T, Rossanese OW, Fesik SW. Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation. Angew Chem Int Ed Engl. 2012 May 8. doi: 10.1002/anie.201201358. PMID:22566140 doi:10.1002/anie.201201358
