9hl2
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of A56/K2 (vaccinia virus)== | |
| - | + | <StructureSection load='9hl2' size='340' side='right'caption='[[9hl2]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9hl2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_Western_Reserve Vaccinia virus Western Reserve]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HL2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hl2 OCA], [https://pdbe.org/9hl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hl2 RCSB], [https://www.ebi.ac.uk/pdbsum/9hl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hl2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PG040_VACCW PG040_VACCW] Negatively regulates superinfection and syncytium formation in infected host cells. Acts in concert with OPG185/A56 protein at the host cell membrane by interacting with and inhibiting the mature virion entry/fusion complex (EFC). This mechanism ensures that new virions released from the cell cannot enter already infected cells.<ref>PMID:32132239</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Vaccinia virus Western Reserve]] | ||
| + | [[Category: Guardado-Calvo P]] | ||
| + | [[Category: Meola A]] | ||
| + | [[Category: Vernuccio R]] | ||
Current revision
Structure of A56/K2 (vaccinia virus)
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