1fzc

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[[Image:1fzc.gif|left|200px]]
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[[Image:1fzc.png|left|200px]]
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==Overview==
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{{ABSTRACT_9628725}}
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Factor XIII-cross-linked fragment D (double-D) from human fibrin was crystallized in the presence of two different peptide ligands and the X-ray structure determined at 2.3 A. The peptide Gly-Pro-Arg-Pro-amide, which is an analogue of the knob exposed by the thrombin-catalyzed removal of fibrinopeptide A, was found to reside in the gamma-chain holes, and the peptide Gly-His-Arg-Pro-amide, which corresponds to the beta-chain knob, was found in the homologous beta-chain holes. The structure shows for the first time that the beta-chain knob does indeed bind to a homologous hole on the beta-chain. The gamma- and beta-chain holes are structurally very similar, and it is remarkable they are able to distinguish between these two peptides that differ by a single amino acid. Additionally, we have found that the beta-chain domain, like its gamma-chain counterpart, binds calcium.
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==About this Structure==
==About this Structure==
1FZC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1FZC with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb83_1.html Fibrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZC OCA].
1FZC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1FZC with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb83_1.html Fibrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZC OCA].
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==Reference==
 
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Crystal structure of fragment double-D from human fibrin with two different bound ligands., Everse SJ, Spraggon G, Veerapandian L, Riley M, Doolittle RF, Biochemistry. 1998 Jun 16;37(24):8637-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9628725 9628725]
 
[[Category: Fibrin]]
[[Category: Fibrin]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Crosslinking]]
[[Category: Crosslinking]]
[[Category: Plasma protein]]
[[Category: Plasma protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:56:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:24:14 2008''

Revision as of 14:24, 26 June 2008

Image:1fzc.png

Template:STRUCTURE 1fzc

CRYSTAL STRUCTURE OF FRAGMENT DOUBLE-D FROM HUMAN FIBRIN WITH TWO DIFFERENT BOUND LIGANDS


Template:ABSTRACT 9628725

About this Structure

1FZC is a Protein complex structure of sequences from Homo sapiens. The following page contains interesting information on the relation of 1FZC with [Fibrin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:24:14 2008

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