This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1m1j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1m1j.gif|left|200px]]
+
[[Image:1m1j.png|left|200px]]
<!--
<!--
Line 12: Line 12:
-
==Overview==
+
{{ABSTRACT_11601975}}
-
The crystal structure of native chicken fibrinogen (320 kDa) complexed with two synthetic peptides has been determined at a resolution of 2.7 A. The structure provides the first atomic-resolution view of the polypeptide chain arrangement in the central domain where the two halves of the molecule are joined, as well as of a putative thrombin-binding site. The amino-terminal segments of the alpha and beta chains, including fibrinopeptides A and B, are not visible in electron density maps, however, and must be highly disordered. The alphaC domain is also very disordered. A residue by residue analysis of the coiled coils with regard to temperature factor shows a strong correlation between mobility and plasmin attack sites. It is concluded that structural flexibility is an inherent feature of fibrinogen that plays a key role in both its conversion to fibrin and its subsequent destruction by plasmin.
+
==About this Structure==
==About this Structure==
1M1J is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1jfe 1jfe]. The following page contains interesting information on the relation of 1M1J with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb83_1.html Fibrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1J OCA].
1M1J is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1jfe 1jfe]. The following page contains interesting information on the relation of 1M1J with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb83_1.html Fibrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1J OCA].
- 
-
==Reference==
 
-
Crystal structure of native chicken fibrinogen at 2.7 A resolution., Yang Z, Kollman JM, Pandi L, Doolittle RF, Biochemistry. 2001 Oct 23;40(42):12515-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11601975 11601975]
 
[[Category: Fibrin]]
[[Category: Fibrin]]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
Line 30: Line 26:
[[Category: Disulfide ring]]
[[Category: Disulfide ring]]
[[Category: Fibrinogen]]
[[Category: Fibrinogen]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:31:15 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:42:08 2008''

Revision as of 14:42, 26 June 2008


PDB ID 1m1j

Drag the structure with the mouse to rotate
1m1j, resolution 2.70Å ()
Ligands: , ,
Related: 1ei3, 1fzc
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of native chicken fibrinogen with two different bound ligands


Template:ABSTRACT 11601975

About this Structure

1M1J is a Protein complex structure of sequences from Gallus gallus. This structure supersedes the now removed PDB entry 1jfe. The following page contains interesting information on the relation of 1M1J with [Fibrin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:42:08 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1m1j"
Personal tools