1m1j

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[[Image:1m1j.gif|left|200px]]
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==Overview==
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{{ABSTRACT_11601975}}
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The crystal structure of native chicken fibrinogen (320 kDa) complexed with two synthetic peptides has been determined at a resolution of 2.7 A. The structure provides the first atomic-resolution view of the polypeptide chain arrangement in the central domain where the two halves of the molecule are joined, as well as of a putative thrombin-binding site. The amino-terminal segments of the alpha and beta chains, including fibrinopeptides A and B, are not visible in electron density maps, however, and must be highly disordered. The alphaC domain is also very disordered. A residue by residue analysis of the coiled coils with regard to temperature factor shows a strong correlation between mobility and plasmin attack sites. It is concluded that structural flexibility is an inherent feature of fibrinogen that plays a key role in both its conversion to fibrin and its subsequent destruction by plasmin.
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==About this Structure==
==About this Structure==
1M1J is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1jfe 1jfe]. The following page contains interesting information on the relation of 1M1J with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb83_1.html Fibrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1J OCA].
1M1J is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1jfe 1jfe]. The following page contains interesting information on the relation of 1M1J with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb83_1.html Fibrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1J OCA].
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==Reference==
 
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Crystal structure of native chicken fibrinogen at 2.7 A resolution., Yang Z, Kollman JM, Pandi L, Doolittle RF, Biochemistry. 2001 Oct 23;40(42):12515-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11601975 11601975]
 
[[Category: Fibrin]]
[[Category: Fibrin]]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Disulfide ring]]
[[Category: Disulfide ring]]
[[Category: Fibrinogen]]
[[Category: Fibrinogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:31:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:42:08 2008''

Revision as of 14:42, 26 June 2008


PDB ID 1m1j

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1m1j, resolution 2.70Å ()
Ligands: , ,
Related: 1ei3, 1fzc
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of native chicken fibrinogen with two different bound ligands


Template:ABSTRACT 11601975

About this Structure

1M1J is a Protein complex structure of sequences from Gallus gallus. This structure supersedes the now removed PDB entry 1jfe. The following page contains interesting information on the relation of 1M1J with [Fibrin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:42:08 2008

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