1umg

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[[Image:1umg.gif|left|200px]]
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{{STRUCTURE_1umg| PDB=1umg | SCENE= }}
{{STRUCTURE_1umg| PDB=1umg | SCENE= }}
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'''Crystal strucure of fructose-1,6-bisphosphatase'''
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===Crystal strucure of fructose-1,6-bisphosphatase===
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==Overview==
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As the first structure of the novel class of fructose-1,6-bisphosphatase (FBPase) present in thermophilic archaea, we solved the crystal structure of the ST0318 gene product (St-Fbp) of Sulfolobus tokodaii strain 7. The St-Fbp structure comprises a homooctamer of the 422 point-group. The protein folds as a four-layer alpha-beta-beta-alpha sandwich with a novel topology, which is completely different from the sugar phosphatase fold. The structure contains an unhydrolyzed FBP molecule in the open-keto form, as well as four hexacoordinated magnesium ions around the 1-phosphoryl group of FBP. The arrangement of the catalytic side chains and metal ligands is consistent with the three-metal ion assisted catalysis proposed for conventional FBPases. The structure provides an insight into the structural basis of the strict substrate specificity of St-Fbp.
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(as it appears on PubMed at http://www.pubmed.gov), where 15274916 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15274916}}
==About this Structure==
==About this Structure==
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[[Category: Phosphatase]]
[[Category: Phosphatase]]
[[Category: Three metal-assisted mechanism]]
[[Category: Three metal-assisted mechanism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:25:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:03:07 2008''

Revision as of 14:03, 27 July 2008

Image:1umg.png

Template:STRUCTURE 1umg

Crystal strucure of fructose-1,6-bisphosphatase

Template:ABSTRACT PUBMED 15274916

About this Structure

1UMG is a Single protein structure of sequence from Sulfolobus tokodaii. Full crystallographic information is available from OCA.

Reference

The first crystal structure of the novel class of fructose-1,6-bisphosphatase present in thermophilic archaea., Nishimasu H, Fushinobu S, Shoun H, Wakagi T, Structure. 2004 Jun;12(6):949-59. PMID:15274916

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