3bw8

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{{STRUCTURE_3bw8| PDB=3bw8 | SCENE= }}
{{STRUCTURE_3bw8| PDB=3bw8 | SCENE= }}
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'''Crystal structure of the Clostridium limosum C3 exoenzyme'''
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===Crystal structure of the Clostridium limosum C3 exoenzyme===
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==Overview==
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C3-like toxins ADP-ribosylate and inactivate Rho GTPases. Seven C3-like ADP-ribosyltransferases produced by Clostridium botulinum, Clostridium limosum, Bacillus cereus and Staphylococcus aureus were identified and two representatives - C3bot from C. botulinum and C3stau2 from S. aureus - were crystallized. Here we present the 1.8A structure of C. limosum C3 transferase C3lim and compare it to the structures of other family members. In contrast to the structure of apo-C3bot, the canonical ADP-ribosylating turn turn motif is observed in a primed conformation, ready for NAD binding. This suggests an impact on the binding mode of NAD and on the transferase reaction. The crystal structure explains why auto-ADP-ribosylation of C3lim at Arg41 interferes with the ADP-ribosyltransferase activity of the toxin.
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(as it appears on PubMed at http://www.pubmed.gov), where 18325337 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18325337}}
==About this Structure==
==About this Structure==
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[[Category: Ribosylating toxin]]
[[Category: Ribosylating toxin]]
[[Category: Secreted]]
[[Category: Secreted]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:09:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:59:17 2008''

Revision as of 13:59, 28 July 2008

Image:3bw8.png

Template:STRUCTURE 3bw8

Crystal structure of the Clostridium limosum C3 exoenzyme

Template:ABSTRACT PUBMED 18325337

About this Structure

3BW8 is a Single protein structure of sequence from Clostridium limosum. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Clostridium limosum C3 exoenzyme., Vogelsgesang M, Stieglitz B, Herrmann C, Pautsch A, Aktories K, FEBS Lett. 2008 Apr 2;582(7):1032-6. Epub 2008 Mar 4. PMID:18325337

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