User:Wayne Chang
From Proteopedia
(Difference between revisions)
(→Outline) |
|||
| Line 41: | Line 41: | ||
== Outline == | == Outline == | ||
| + | '''Work in Progress''' | ||
| + | |||
Glutamine synthetase (GS) catalyzes the ATP dependent condensation of glutamate and ammonia, producing, glutamine, ADP, and an inorganic phosphate group. | Glutamine synthetase (GS) catalyzes the ATP dependent condensation of glutamate and ammonia, producing, glutamine, ADP, and an inorganic phosphate group. | ||
Revision as of 21:48, 15 November 2008
Contents |
Assignment 12: IVC: Ammonium Binding Site
Mapping the Ammonium binding site and explaining how it contributes to catalysis.
Chang, Yu-Wei and Kaushal, Pankaj.
BIOL 430: Biological Chemistry, Fall 2008.
University of Maryland, Baltimore County (UMBC).
Script Exercises
|
Outline
Work in Progress
Glutamine synthetase (GS) catalyzes the ATP dependent condensation of glutamate and ammonia, producing, glutamine, ADP, and an inorganic phosphate group.
Glutamate + ATP + NH3 → Glutamine + ADP + phosphate
Ammonium ion is thought to bind to GS at the monovalent cation binding site for Tl(+) and Cs(+) ions.
References
1. Liaw, S-H, et.al.,Discovery of the ammonium substrate site on glutamine synthetase, a third cation binding site Protein Sci. 1995 4: 2358-2365[1]
