User:Wayne Decatur/Sandbox
From Proteopedia
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<applet load='2hty2hu4_j.pdb' size='500' frame='true' align='right' caption='Morph of N1 alone (2hty) to N1 complexed with Tamiflu (2hu4). The position where Tamiflu will bind is shown translucent except when bound in the empirically-determined model.' scene='Avian_Influenza_Neuraminidase,_Tamiflu_and_Relenza/Morph_2hty_to_2hu4/2' /> | <applet load='2hty2hu4_j.pdb' size='500' frame='true' align='right' caption='Morph of N1 alone (2hty) to N1 complexed with Tamiflu (2hu4). The position where Tamiflu will bind is shown translucent except when bound in the empirically-determined model.' scene='Avian_Influenza_Neuraminidase,_Tamiflu_and_Relenza/Morph_2hty_to_2hu4/2' /> | ||
Revision as of 09:52, 19 November 2008
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Here is a schematic illustration of the two strands of this silencing RNA (siRNA):
5'-pCGUACGCGUCACGCGUACGUU-OH-3'
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3'-OH-UUGCAUGCGCACUGCGCAUGCp-5'
HOW TO MAKE AN ANIMATION USING PROTEOPEDIA SCREEN AUTHORING TOOLS AND THE CONSOLE
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Tamiflu was designed to fit N2/N9, so it is serendipitous that it works on N1. In fact, when the structure of N1 was determined[1], the loop comprising residues 147-152 was not in a suitable position to participate in binding Tamiflu. However, the complex of N1 with Tamiflu revealed that this loop is pulled into proper contact with the drug in an induced fit manner[1]. A morph from N1 alone (2hty) to N1 complexed with Tamiflu (2hu4)[2] shows the change in position of this loop ().
The binding of Tamiflu to N1 pulls the sidechains of two conserved residues, , closer to the inhibitor.
