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The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from Torpedo california) complex shows that E2020 has a along the active-site gorge, extending from the anionic subsite () of the active site, at the bottom, to the peripheral anionic site (), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only . Read more...

• Hemoglobin - the protein in your blood responsible for oxygen transport
• HIV-1 protease - a protein made by the HIV virus that is crucial to its infectious capacity
• Lac repressor - a repressor that controls the expression of bacterial enzymes involved in lactose metabolism

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• 2q66 - yeast poly(a)-polymerase, adds poly-A tails to nascent messenger RNAs
• Hydrogen bonds
• Morphs - visualizing conformational changes

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• a reference resource for understanding protein 3D structure-function relationships
• Example: Acetylcholinesterase bound to Aricept, an anti-Alzheimer's drug (choose a MotM for this, and create bustop on that page). For example check out the Molecule of the Month series by David Goodsell which supplement the Molecule of the Month at the PDB link

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