Proteopedia:Main page develop

The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from Torpedo california) complex shows that E2020 has a along the active-site gorge, extending from the anionic subsite () of the active site, at the bottom, to the peripheral anionic site (), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only . Read more...

• Hemoglobin - the protein in your blood responsible for oxygen transport
• HIV-1 protease - a protein made by the HIV virus that is crucial to its infectious capacity
• Lac repressor - a repressor that controls the expression of bacterial enzymes involved in lactose metabolism

• All PDB entries (over 54,000) have pages

• Go takes you directly to the page if it exists,
• Search gives you search results

• 2q66 - yeast poly(a)-polymerase, adds poly-A tails to nascent messenger RNAs
• Hydrogen bonds
• Morphs - visualizing conformational changes

Green links are easy to make! We encourage you to edit pages freely and to add new pages.

You will need a user account in order to edit or add pages. Please go ahead and request a user account.

If you have any questions, you can email .

These resources may help you familiarize yourself with the editing process. Trust us, the editing process is very simple: All text is edited the same way that Wikipedia is edited, so it must be easy! And all scenes (green links) are created using our user-friendly Scene authoring tools. Of course it helps to familiarize yourself with the site and how to go about editing, so check out these resources:

• The Proteopedia Video Guide is a narrated video guide that serves both as a starting point as well as a reference.
• The Editing Help Page.
• The help page for the Scene authoring tools.
• Proteopedia:Policies and the Proteopedia: Email list

• A resource for understanding protein 3D structure-function relationships
  • Example: 1wsu - C-terminal domain of elongation factor selB complexed with SECIS RNA, featured in the Molecule of the Month at the PDB

• develop tutorials or molecular scenes to project during lectures
  • Examples: Teaching Scenes, Tutorials, and Educators' Pages.
• Assign students to construct pages in Proteopedia for class projects or reports:
  • see Student Projects. See also Teaching Strategies Using Proteopedia.

You may protect your teaching pages from unwanted editing by others -- see Help:Protected Pages.

• create supplementary materials for your journal publications
• create pages about your research team or institute, highlighting structures you have researched.
• for examples, see Research Groups.

You may protect such pages from unwanted editing by others -- see Help:Protected Pages.