Doppel
From Proteopedia
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(New page: Doppel (Dpl), named for '''''do'''wnstream '''p'''rion '''p'''rotein like''<ref>1</ref>, is a homolog of the prion protein (PrP). It is a cell surface glycoprotein. ==Structure of Dpl...)
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Revision as of 12:01, 14 December 2008
Doppel (Dpl), named for downstream prion protein like[1], is a homolog of the prion protein (PrP). It is a cell surface glycoprotein.
Structure of Dpl
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| 1lg4, 20 NMR models () | |||||||||
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| Gene: | Prnd (Homo sapiens) | ||||||||
| Related: | 1i17 | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Dpl has the same fold as PrP, with three alpha helices and two short beta strands, however it differs in that the third helix has a significant kink in it and it also contains two disulphide bonds.
References
Moore et al. (1999) Ataxia in Prion Protein (PrP)-deficient Mice is Associated with Upregulation of the Novel PrP-like Protein Doppel J. Mol. Biol. 292, 797-817
