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Poly(A) polymerase binds specifically to ATP and adds it the end of a messenger RNA chain. This structure contains an oligo(A) polynucleotide with five nucleotides, an ATP molecule, and a magnesium ion. … In the , the enzyme is in blue backbone representation, the RNA chain is in yellow, the ATP is in red, the magnesium is in green, and ALA154 is in magenta. Several mechanisms are used to achieve the specificity for ATP. The magnesium is coordinated by , and the magnesium coordinates with the phosphates of ATP, positioning the nucleotide in the active site. The adenine base is sandwiched between the . Read more...

• Hemoglobin - the protein in your blood responsible for oxygen transport
• HIV-1 protease - a protein made by the HIV virus that is crucial to its infectious capacity
• Lac repressor - a repressor that controls the expression of bacterial enzymes involved in lactose metabolism

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• 2q66 - yeast poly(a)-polymerase, adds poly-A tails to nascent messenger RNAs
• Hydrogen bonds
• Morphs - visualizing conformational changes

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