Tositumomab

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Pharmacokinetics

Anti-CD20 Monoclonal Antibody Pharmacokinetics [1]
Parameter Tositumomab Ofatumumab Rituximab Ibritumomab
Tmax (hr) Tositumomab 7.6 Rituximab Ibritumomab
Cmax (ng/ml) Tositumomab 167000 Rituximab Ibritumomab
Bioavailability (%) Tositumomab Ofatumumab Rituximab Ibritumomab
Protein Binding (%) Tositumomab Ofatumumab Rituximab Ibritumomab
T1/2 (hr) 64.8 68 Rituximab Ibritumomab
AUC (ng/ml/hr) Tositumomab 32939000 Rituximab Ibritumomab
Clearance (L/h) .078 .017 Rituximab Ibritumomab
IC50 (nM) Tositumomab Ofatumumab Rituximab Ibritumomab
Dosage (mg) Tositumomab 500 (4th Infusion) Rituximab Ibritumomab
Metabolism Tositumomab Ofatumumab Rituximab Ibritumomab

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