StudioG24SecL04Tpc5

From Proteopedia

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	spinqualitylabelsall models PDB ID 1l8w.pdb Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
	Variable Major Protein (VMP)-like sequence Expressed (1l8w), resolution 2.3Å *This representation of VlsE illustrates the only crystal structure available on the PDB site.

Contents 1 VlsE 2 Structural Overview 3 Antigenicity 4 Function in Immune System Evasion 5 Additional Links

VlsE

spinqualitylabelsall models IR6:Immunodominate Region of VlsE Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

VlsE is shown to be composed of four sub-units, each consisting of a variable domain flanked by two invariable domains (Liang). The variable domains themselves contain six variable regions (VR) interspersed amongst six invariable regions (IR). The IRs are embedded deep within the protein covered by alpha helical loops. They are shielded by the VRs.

Structural Overview

Antigenicity

Function in Immune System Evasion

Additional Links

Antigenic Variation
Lyme Disease