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Variable Major Protein (VMP)-like sequence Expressed (1l8w), resolution 2.3Å

*This representation of VlsE illustrates the only crystal structure available on the PDB site.

1 VlsE
2 Structural Overview
3 Antigenicity
4 Function in Immune System Evasion
5 Additional Links

VlsE

VlsE is shown to be composed of four sub-units, each consisting of a variable domain flanked by two invariable domains (Liang). The variable domains themselves contain six variable regions (VR) interspersed amongst six invariable regions (IR). The IRs are embedded deep within the protein covered by alpha helical loops. They are shielded by the VRs.