Enolase multiple sequence alignment
From Proteopedia
Multiple Sequence Alignment (MSA) for enolase, an enzyme in glycolysis.
Key: IDENTICAL(*) SIMILAR(.) different Consensus Percentage is set to 100%.
1 ENO_DROME| Drosophila melanogaster <b>G</b>vh<b>EA</b>L<b>E</b>l<b>RD</b> nD<b>K</b>anYh<b>GK</b>S <b>V</b>lk<b>AV</b>ghV<b>N</b>d tLgpelIkan ldvvd<b>Q</b>asI<b>D</b> 91<br> 2 ENOA_HUMAN| Homo sapiens <b>G</b>iy<b>EA</b>L<b>E</b>l<b>RD</b> nD<b>K</b>trYm<b>GK</b>G <b>V</b>sk<b>AV</b>ehI<b>N</b>k tIapalVskk lnvte<b>Q</b>ekI<b>D</b> 90<br> 3 ENO_METJA| Methanococcus janaschii <b>G</b>th<b>EA</b>L<b>E</b>l<b>RD</b> kE<b>K</b>-rFg<b>GK</b>G <b>V</b>lm<b>AV</b>enV<b>N</b>s iIrpeiLg-- ydarm<b>Q</b>reI<b>D</b> 97<br> 4 ENO_ECOLI| Escherichia coli <b>G</b>sr<b>EA</b>L<b>E</b>l<b>RD</b> gD<b>K</b>srFl<b>GK</b>G <b>V</b>tk<b>AV</b>aaV<b>N</b>g pIaqalIg-- kdakd<b>Q</b>agI<b>D</b> 90<br> 5 ENO_BACSU| Bacillus subtilis <b>G</b>ey<b>EA</b>V<b>E</b>l<b>RD</b> gD<b>K</b>drYl<b>GK</b>G <b>V</b>lt<b>AV</b>nnV<b>N</b>e iIapelLg-- fdvte<b>Q</b>naI<b>D</b> 91<br> 6 4ENL Yeast| Saccharomyces cerevisiae <b>G</b>vh<b>EA</b>L<b>E</b>m<b>RD</b> gD<b>K</b>skWm<b>GK</b>G <b>V</b>lh<b>AV</b>knV<b>N</b>d vIapafVkan idvsd<b>Q</b>kaV<b>D</b> 90<o:p></o:p></span></p> <p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New"; mso-bidi-font-family:"Courier New"'><span style="mso-spacerun: yes"> </span>*<span style="mso-spacerun: yes"> </span>**.* **<span style="mso-spacerun: yes"> </span>.*<span style="mso-spacerun: yes"> </span>. **. *<span style="mso-spacerun: yes"> </span>**<span style="mso-spacerun: yes"> </span>.*<span style="mso-spacerun: yes"> </span>.<span style="mso-spacerun: yes"> </span><span style="mso-spacerun: yes"> </span>.<span style="mso-spacerun: yes"> </span>*<span style="mso-spacerun: yes"> </span>.*<br> <br> 1 ENO_DROME| Drosophila melanogaster nfm<b>I</b>kl<b>DGT</b>e <b>NK</b>SKf<b>GANAI</b> <b>L</b>G<b>VS</b>l<b>A</b>vaK<b>A</b> G<b>A</b>akkgv<b>PLY</b> khIAdlagn- 140<br> 2 ENOA_HUMAN| Homo sapiens klm<b>I</b>em<b>DGT</b>e <b>NK</b>SKf<b>GANAI</b> <b>L</b>G<b>VS</b>l<b>A</b>vcK<b>A</b> G<b>A</b>vekgv<b>PLY</b> rhIAdlagn- 139<br> 3 ENO_METJA| Methanococcus janaschii tim<b>I</b>el<b>DGT</b>p <b>NK</b>SRl<b>GANAI</b> <b>L</b>A<b>VS</b>l<b>A</b>vaK<b>A</b> A<b>A</b>ataki<b>PLY</b> kyLGgfn--- 144<br> 4 ENO_ECOLI| Escherichia coli kim<b>I</b>dl<b>DGT</b>e <b>NK</b>SKf<b>GANAI</b> <b>L</b>A<b>VS</b>l<b>A</b>naK<b>A</b> A<b>A</b>aakgm<b>PLY</b> ehIAelngt- 139<br> 5 ENO_BACSU| Bacillus subtilis qll<b>I</b>el<b>DGT</b>e <b>NK</b>GKl<b>GANAI</b> <b>L</b>G<b>VS</b>m<b>A</b>caR<b>A</b> A<b>A</b>dflqi<b>PLY</b> qyLGgfn--- 138<br> 6 4ENL Yeast| Saccharomyces cerevisiae dfl<b>I</b>sl<b>DGT</b>a <b>NK</b>SKl<b>GANAI</b> <b>L</b>G<b>VS</b>l<b>A</b>asR<b>A</b> A<b>A</b>aeknv<b>PLY</b> khLAdlsksk 140<o:p></o:p></span></p> <p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New"; mso-bidi-font-family:"Courier New"'><span style="mso-spacerun: yes"> </span>*<span style="mso-spacerun: yes"> </span>***<span style="mso-spacerun: yes"> </span>**.. ***** *.** *<span style="mso-spacerun: yes"> </span>.* .*<span style="mso-spacerun: yes"> </span>***<span style="mso-spacerun: yes"> </span>.<br> <br> 1 ENO_DROME| Drosophila melanogaster -keiil<b>PVP</b>a f<b>N</b>VI<b>NGG</b>s<b>HA</b> gnkLam<b>QEFM</b> <b>I</b>l<b>P</b>t<b>GA</b>tsft <b>EA</b>mKm<b>G</b>SeVY 189<br> 2 ENOA_HUMAN| Homo sapiens -sevil<b>PVP</b>a f<b>N</b>VI<b>NGG</b>s<b>HA</b> gnkLam<b>QEFM</b> <b>I</b>l<b>P</b>v<b>GA</b>anfr <b>EA</b>mRi<b>G</b>AeVY 188<br> 3 ENO_METJA| Methanococcus janaschii --syvm<b>PVP</b>m m<b>N</b>VI<b>NGG</b>k<b>HA</b> gndLdl<b>QEFM</b> <b>I</b>m<b>P</b>v<b>GA</b>tsis <b>EA</b>vRm<b>G</b>SeVY 192<br> 4 ENO_ECOLI| Escherichia coli pgkysm<b>PVP</b>m m<b>N</b>II<b>NGG</b>e<b>HA</b> dnnVdi<b>QEFM</b> <b>I</b>q<b>P</b>v<b>GA</b>ktvk <b>EA</b>iRm<b>G</b>SeVF 189<br> 5 ENO_BACSU| Bacillus subtilis --sktl<b>PVP</b>m m<b>N</b>IV<b>NGG</b>e<b>HA</b> dnnVdi<b>QEFM</b> <b>I</b>m<b>P</b>v<b>GA</b>pnfr <b>EA</b>lRm<b>G</b>AqIF 186<br> 6 4ENL Yeast| Saccharomyces cerevisiae tspyvl<b>PVP</b>f l<b>N</b>VL<b>NGG</b>s<b>HA</b> ggaLal<b>QEFM</b> <b>I</b>a<b>P</b>t<b>GA</b>ktfa <b>EA</b>lRi<b>G</b>SeVY 190<o:p></o:p></span></p> <p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New"; mso-bidi-font-family:"Courier New"'><span style="mso-spacerun: yes"> </span>***<span style="mso-spacerun: yes"> </span>*..*** **<span style="mso-spacerun: yes"> </span>.<span style="mso-spacerun: yes"> </span>**** * * **<span style="mso-spacerun: yes"> </span>** . *. ..<o:p></o:p></span></p> <span style='font-size:10.0pt;font-family:"Courier New";mso-fareast-font-family: "Times New Roman";mso-bidi-font-family:"Courier New";mso-ansi-language:EN-US; mso-fareast-language:EN-US'><br clear=ALL style='page-break-before:always'> </span> <p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New"; mso-bidi-font-family:"Courier New"'> 1 ENO_DROME| Drosophila melanogaster <b>H</b>h<b>L</b>knVikaK fgldata<b>VGD</b> <b>EGG</b>f<b>AP</b>nIqs nk<b>E</b>A<b>L</b>nlIsd AIak<b>AG</b>yt-- 237<br> 2 ENOA_HUMAN| Homo sapiens <b>H</b>n<b>L</b>knVikeK ygkdatn<b>VGD</b> <b>EGG</b>f<b>AP</b>nIle nk<b>E</b>G<b>L</b>elLkt AIgk<b>AG</b>yt-- 236<br> 3 ENO_METJA| Methanococcus janaschii <b>H</b>v<b>L</b>knVileK ygknavn<b>VGD</b> <b>EGG</b>f<b>AP</b>pLkt sr<b>E</b>A<b>L</b>dlLte SVkk<b>AG</b>ye-- 240<br> 4 ENO_ECOLI| Escherichia coli <b>H</b>h<b>L</b>akVlkaK g--mnta<b>VGD</b> <b>EGG</b>y<b>AP</b>nLgs na<b>E</b>A<b>L</b>avIae AVka<b>AG</b>yelg 237<br> 5 ENO_BACSU| Bacillus subtilis <b>H</b>s<b>L</b>ksVlsaK g--lnta<b>VGD</b> <b>EGG</b>f<b>AP</b>nLgs ne<b>E</b>A<b>L</b>qtIve AIek<b>AG</b>fkpg 234<br> 6 4ENL Yeast| Saccharomyces cerevisiae <b>H</b>n<b>L</b>ksLtkkR ygasagn<b>VGD</b> <b>EGG</b>v<b>AP</b>nIqt ae<b>E</b>A<b>L</b>dlIvd AIka<b>AG</b>hd—238<o:p></o:p></span></p> <p class=MsoNormal><!--[if gte vml 1]><v:rect id="_x0000_s1027" style='position:absolute; margin-left:243.1pt;margin-top:13.05pt;width:140.25pt;height:90pt;z-index:251657728; mso-wrap-edited:f' wrapcoords="-346 -180 -462 360 -462 22860 22293 22860 22408 1260 22177 0 21831 -180 -346 -180" filled="f" fillcolor="#3f80cd" strokecolor="red" strokeweight="1.5pt"> <v:fill opacity="3932f" color2="#9bc1ff" o:detectmouseclick="t" focusposition="" focussize=",90" type="gradient"> <o:fill v:ext="view" type="gradientUnscaled"/> </v:fill> <v:shadow on="t" opacity="22938f" css:blur="38100f" offset="0"/> <v:textbox inset=",7.2pt,,7.2pt"/> </v:rect><![endif]--><![if !vml]><span style='mso-ignore:vglayout;position: relative;z-index:251657728'><span style='position:absolute;left:220px; top:-33px;width:155px;height:106px'><img width=155 height=106 src="msa3d_4enl_msa_files/image001.gif" v:shapes="_x0000_s1027"></span></span><![endif]><span style='font-size:10.0pt;font-family:"Courier New";mso-bidi-font-family:"Courier New"'><span style="mso-spacerun: yes"> </span><span style="mso-spacerun: yes"> </span>* *<span style="mso-spacerun: yes"> </span>.<span style="mso-spacerun: yes"> </span>.<span style="mso-spacerun: yes"> </span>*** *** ** .<span style="mso-spacerun: yes"> </span>*.*<span style="mso-spacerun: yes"> </span>.<span style="mso-spacerun: yes"> </span>..<span style="mso-spacerun: yes"> </span>** <br> <span style="mso-spacerun: yes"> </span>~~~~~~~~~~~~~~~~~~~~~<br> 1 ENO_DROME| Drosophila melanogaster gkIeiGm<b>D</b>v<b>A</b> A<b>SEF</b>Yk--d<b>G</b> q<b>Y</b>dLdfknek sdksqwlpad klanlykefi 285<br> 2 ENOA_HUMAN| Homo sapiens dkVviGm<b>D</b>v<b>A</b> A<b>SEF</b>Fr--s<b>G</b> k<b>Y</b>dLdfksp- ddpsryispd qladlyksfi 283<br> 3 ENO_METJA| Methanococcus janaschii deVvfAl<b>D</b>a<b>A</b> A<b>SEF</b>Yk--d<b>G</b> y<b>Y</b>yVegkk-- ------ltre elldyykalv 280<br> 4 ENO_ECOLI| Escherichia coli kdItlAm<b>D</b>c<b>A</b> A<b>SEF</b>Yk--d<b>G</b> k<b>Y</b>vLagegn- ----kaftse efthfleelt 280<br> 5 ENO_BACSU| Bacillus subtilis eeVklAm<b>D</b>a<b>A</b> S<b>SEF</b>Ynked<b>G</b> k<b>Y</b>hLsgeg-- ----vvktsa emvdwyeelv 278<br> 6 4ENL Yeast| Saccharomyces cerevisiae gkVkiGl<b>D</b>c<b>A</b> S<b>SEF</b>Fk--d<b>G</b> k<b>Y</b>dLdfknpn sdkskwltgp qladlyhslm 286<o:p></o:p></span></p> <p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New"; mso-bidi-font-family:"Courier New"'><span style="mso-spacerun: yes"> </span><span style="mso-spacerun: yes"> </span>.<span style="mso-spacerun: yes"> </span>. * * .***.<span style="mso-spacerun: yes"> </span>*<span style="mso-spacerun: yes"> </span>* .<span style="mso-spacerun: yes"> </span><br> <span style="mso-spacerun: yes"> </span>~~~~~~~~~~~~~~~~~~~~~<br> 1 ENO_DROME| Drosophila melanogaster kdF<b>P</b>IV<b>SIED</b> pfdqdhWeAw snltgctd-- I<b>Q</b>I<b>V</b>G<b>DDL</b>t<b>V</b> <b>TN</b>pkrIatAV 333<br> 2 ENOA_HUMAN| Homo sapiens kdY<b>P</b>VV<b>SIED</b> pfdqddWgAw qkftasag-- I<b>Q</b>V<b>V</b>G<b>DDL</b>t<b>V</b> <b>TN</b>pkrIakAV 331<br> 3 ENO_METJA| Methanococcus janaschii deY<b>P</b>IV<b>SIED</b> pfheedFeGf amitkeld-- I<b>Q</b>I<b>V</b>G<b>DDL</b>f<b>V</b> <b>TN</b>verLrkGI 328<br> 4 ENO_ECOLI| Escherichia coli kqY<b>P</b>IV<b>SIED</b> gldesdWdGf ayqtkvlgdk I<b>Q</b>L<b>V</b>G<b>DDL</b>f<b>V</b> <b>TN</b>tkiLkeGI 330<br> 5 ENO_BACSU| Bacillus subtilis skY<b>P</b>II<b>SIED</b> gldendWeGh kllterlgkk V<b>Q</b>L<b>V</b>G<b>DDL</b>f<b>V</b> <b>TN</b>tkkLseGI 328<br> 6 4ENL Yeast| Saccharomyces cerevisiae krY<b>P</b>IV<b>SIED</b> pfaeddWeAw shffktag-- I<b>Q</b>I<b>V</b>A<b>DDL</b>t<b>V</b> <b>TN</b>pkrIatAI 334
Summary of categories applied to a total of 436 residues in the PDB file sequence for a consensus level setting of 100%: 33% (142) IDENTICAL(*) 16% (68) SIMILAR(.) 52% (226) different Definitions of SIMILAR groups of amino acids: ILV Ile Leu Val hydrophobic, aliphatic / medium-sized side-chain FWY Phe Trp Tyr hydrophobic, aromatic / large side-chain (Tyr polar) KRH Lys Arg His + charge DE Asp Glu - charge GAS Gly Ala Ser small P Pro helix breaking C Cys disulfide-forming TNQM Thr Asn Gln Met polar (except Met)
