4h95

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 4h95

Contents 1 Candida albicans dihydrofolate reductase complexed with NADPH and 6-ethyl-5-{3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine (UCP1006) 2 About this Structure 3 See Also 4 Reference

Candida albicans dihydrofolate reductase complexed with NADPH and 6-ethyl-5-{3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine (UCP1006)

Template:ABSTRACT PUBMED 23375226

About this Structure

4h95 is a 2 chain structure with sequence from candida_stellatoidea Atcc 11006 candida stellatoidea. Full crystallographic information is available from OCA.

See Also

• Dihydrofolate reductase

Reference

• Paulsen JL, Viswanathan K, Wright DL, Anderson AC. Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1279-84. doi: 10.1016/j.bmcl.2013.01.008. , Epub 2013 Jan 11. PMID:23375226 doi:http://dx.doi.org/10.1016/j.bmcl.2013.01.008