User:Gauri Misra/Sandbox 1

Chaperones are proteins that are involved in the non-covalent folding and unfolding of other macromolecules. It exists both in prokaryotes and eukaryotes. Some chaperones are constitutively expressed in the system however, there are other chaperones that are expressed only in response to an external stimulus or stress such as heat and therefore they are referred to as heat shock proteins

[1].

Function

Chaperones bind to the newly synthesized proteins helping them acquire their properly folded 3D structure ^[2] Besides, chaperones help in targeting the native proteins to their respective organelles ^[3] Many protozoan parasites such as Plasmodium falciparum requires these proteins for cytoprotection ^{[4] [5]}maintenance of proteome integrity, and protein homeostasis (proteostasis) critically depend on a complex network of molecular chaperones

Disease

Relevance

Structural highlights

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