1bso

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Image:1bso.gif


PDB ID 1bso

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, resolution 2.23Å
Ligands:
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



12-BROMODODECANOIC ACID BINDS INSIDE THE CALYX OF BOVINE BETA-LACTOGLOBULIN


Overview

The X-ray structure of bovine beta-lactoglobulin with the ligand 12-bromododecanoic acid as a model for fatty acids has been determined at a resolution of 2.23 A in the trigonal lattice Z form. The ligand binds inside the calyx, resolving a long-standing controversy as to where fatty-acid like ligands bind. The carboxylate head group lies at the surface of the molecule, and the lid to the calyx is open at the pH of crystallization (pH 7.3), consistent with the conformation observed in ligand-free bovine beta-lactoglobulin in lattice Z at pH 7.1 and pH 8.2.

About this Structure

1BSO is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

12-Bromododecanoic acid binds inside the calyx of bovine beta-lactoglobulin., Qin BY, Creamer LK, Baker EN, Jameson GB, FEBS Lett. 1998 Nov 6;438(3):272-8. PMID:9827560

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