RING box protein (RBX) makes a heterodimer with cullin. The heterodimer is essential for the protein ubiquitination process. RBX1 is a component of the SCF (Skp1-cullin-F box protein) E3 ubiquitin ligase complex. RBX contains a RING-type zinc finger domain. The RING domain is 40 to 60 residues long and binds two Zn atoms. It is involved in protein-protein interaction.
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Structural highlights