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Nucleoprotein of Influenza A
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Introduction
Viruses with anti-sense RNA genomes, such as the influenza virus carry three core polypeptides inside their viral capsids in order to successfully enter a host and initiate the viral replication cycle. Especially important for viral replication and coordination with the host cell's replication machinery is protein able to bind single-strand RNA scripts (ssRNA). These proteins are commonly referred to as nucleoproteins (NP). The NP is a homo 3-mer - A3 with 499 amino acid residues. Each homomer provides a binding site for the viral RNA script.
